Azathioprine Sodium and Methotrexate
Determining the interaction of Azathioprine Sodium and Methotrexate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Methotrexate inhibits the hepatic metabolism of the thiopurines. Decreased first-pass metabolism and increased bioavailability result. The clinical significance of this interaction has not been determined and is probably insignificant with standard intermittent oral doses of methotrexate. Generally the combination has beneficial effects when used in the treatment of acute lymphoblastic leukemia.
- Balis FM, Holcenberg JS, Zimm S, et al "The effect of methotrexate on the bioavailability of oral 6-mercaptopurine." Clin Pharmacol Ther 41 (1987): 384-7
Generic Name: azathioprine
Brand name: Azasan, Imuran
Synonyms: Azathioprine, AzaTHIOprine
Generic Name: methotrexate
Brand name: Otrexup, Rasuvo, Rheumatrex Dose Pack, Trexall, Xatmep, Methotrexate Sodium, Preservative Free
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Azathioprine Sodium-Methotrexate injection
- Azathioprine Sodium-Methotrexate Injection (Subcutaneous)
- Azathioprine Sodium-Methotrexate Oral Solution
- Azathioprine Sodium-Methotrexate Oral, Injection
- Azathioprine Sodium-Methotrexate Sodium
- Azathioprine Sodium-Methotrexate Tablets
- Methotrexate-Azathioprine Tablets
- Methotrexate-Azedra
- Methotrexate-Azedra Dosimetric
- Methotrexate-Azedra Injection
- Methotrexate-Azedra Therapeutic
- Methotrexate-Azelaic Acid