Azathioprine Sodium and Perindopril and Amlodipine
Determining the interaction of Azathioprine Sodium and Perindopril and Amlodipine and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Rarely, perindopril may add to the effects of azaTHIOprine on white blood cells, increasing the risk of infections. Contact your doctor immediately if you develop signs and symptoms of infection such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Limited clinical data suggest that angiotension converting enzyme (ACE) inhibitors and azathioprine may have additive hematologic effects, resulting in an increased risk of neutropenia or leukopenia during coadministration. Data have been reported for captopril and enalapril. It is unknown whether this effect could occur with other ACE inhibitors.
MANAGEMENT: Patients should be monitored for clinical and laboratory evidence of hematologic abnormalities during concomitant administration. Patients should be advised to report symptoms such as unusual bleeding, bruising, fever, sore throat, mouth sores, or symptoms of infection.
- Edwards CR, Drury P, Penketh A, Damluji SA "Successful reintroduction of captopril following neutropenia." Lancet 1 (1981): 723
- Elijovisch F, Krakoff LR "Captopril associated granulocytopenia in hypertension after renal transplantation ." Lancet 1 (1980): 927-8
- Agencia EspaƱola de Medicamentos y Productos Sanitarios Healthcare "Centro de informaciĆ³n online de medicamentos de la AEMPS - CIMA. Available from: URL: https://cima.aemps.es/cima/publico/home.html." ([2018]):
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Azasan (azaTHIOprine)." Salix Pharmaceuticals, Raleigh, NC.
- Gossmann J, Thurmann P, Bachmann T, Weller S, Kachel HG, Schoeppe W, Scheuermann EH "Mechanism of angiotensin converting enzyme inhibitor-related anemia in renal transplant recipients." Kidney Int 50 (1996): 973-8
Generic Name: azathioprine
Brand name: Azasan, Imuran
Synonyms: Azathioprine, AzaTHIOprine
Generic Name: amlodipine / perindopril
Brand name: Prestalia
Synonyms: Amlodipine and perindopril
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Azathioprine Sodium-Perindopril Arginine, Perindopril Erbumine
- Azathioprine Sodium-Periostat
- Azathioprine Sodium-Perjeta
- Azathioprine Sodium-Perjeta Injection
- Azathioprine Sodium-Perloxx
- Azathioprine Sodium-Permapen Isoject
- Perindopril and Amlodipine-Azathioprine Tablets
- Perindopril and Amlodipine-Azedra
- Perindopril and Amlodipine-Azedra Dosimetric
- Perindopril and Amlodipine-Azedra Injection
- Perindopril and Amlodipine-Azedra Therapeutic
- Perindopril and Amlodipine-Azelaic Acid