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Azathioprine Tablets and Rheumatrex Dose Pack

Determining the interaction of Azathioprine Tablets and Rheumatrex Dose Pack and the possibility of their joint administration.

Check result:

Azathioprine Tablets <> Rheumatrex Dose Pack

Relevance: 14.10.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Methotrexate inhibits the hepatic metabolism of the thiopurines. Decreased first-pass metabolism and increased bioavailability result. The clinical significance of this interaction has not been determined and is probably insignificant with standard intermittent oral doses of methotrexate. Generally the combination has beneficial effects when used in the treatment of acute lymphoblastic leukemia.

References

Balis FM, Holcenberg JS, Zimm S, et al "The effect of methotrexate on the bioavailability of oral 6-mercaptopurine." Clin Pharmacol Ther 41 (1987): 384-7

Azathioprine Tablets

Generic Name: azathioprine

Brand name: Azasan, Imuran

Synonyms: Azathioprine, AzaTHIOprine

What is Azathioprine Tablets?

Rheumatrex Dose Pack

Generic Name: methotrexate

Brand name: Rheumatrex Dose Pack, Trexall, Xatmep, Otrexup, Rasuvo, Methotrexate Sodium, Preservative Free

Synonyms: Rheumatrex

What is Rheumatrex Dose Pack?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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