Azedra and Entex PSE

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Pseudoephedrine may interfere with the effects of iobenguane I-131 in treating your condition. Let your doctor know you are receiving or have recently received pseudoephedrine if you are being prescribed iobenguane I-131. You may need to stop using pseudoephedrine for a certain amount of time before and after starting treatment with iobenguane I-131. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with drugs that reduce catecholamine uptake or deplete catecholamine stores may interfere with iobenguane I-131 uptake into neuroendocrine tumors such as pheochromocytoma and paraganglioma that express high levels of norepinephrine transporter on their cell surfaces. Since iobenguane is similar in structure to norepinephrine and is subject to the same uptake and accumulation pathways as norepinephrine, drugs that alter norepinephrine disposition in adrenergic nerve terminals and presynaptic storage vesicles will likewise affect iobenguane. Dosimetry calculations and efficacy of iobenguane I-131 may be altered. These drugs include central nervous system stimulants (e.g., amphetamines, cocaine, methylphenidate); norepinephrine and dopamine reuptake inhibitors (e.g., phentermine); norepinephrine and serotonin reuptake inhibitors (e.g., tramadol); central monoamine depleting drugs (e.g., reserpine); nonselective beta-adrenergic blockers (e.g., labetalol); alpha agonists or alpha/beta agonists (e.g., pseudoephedrine, phenylephrine, ephedrine, phenylpropanolamine, naphazoline); monoamine oxidase inhibitors; tricyclic antidepressants; norepinephrine reuptake inhibitors (e.g., bupropion, duloxetine, mirtazapine, venlafaxine); and botanicals that may inhibit reuptake of norepinephrine, serotonin, or dopamine (e.g., ephedra, ma huang, St John's wort, yohimbine). These drugs were not permitted in clinical trials that assessed the safety and efficacy of iobenguane I-131.

MANAGEMENT: Drugs that reduce catecholamine uptake or deplete catecholamine stores should be discontinued for at least five biological half-lives before administration of either the dosimetry dose or a therapeutic dose of iobenguane I-131. Do not administer these drugs until at least 7 days after each iobenguane I-131 dose. Patients should be monitored for the occurrence of clinically significant withdrawal symptoms, especially patients with elevated levels of circulating catecholamines and their metabolites.

Azedra

Generic Name: iobenguane I 131

Brand name: Azedra, AdreView

Synonyms: Azedra Injection

What is Azedra?

Entex PSE

Generic Name: guaifenesin / pseudoephedrine

Brand name: Entex PSE, Zephrex LA, Ambifed-G, Despec-SR, Entex T, Maxifed, Mucinex D, Mucinex D Max Strength, Poly-Vent IR, Respaire-30, Robitussin Severe Congestion, Sinutab Non Drying, Triaminic Softchews Chest Congestion, Tusnel Pediatric Drops, Guaimax-D, Anatuss LA, Touro LA, Medent, Fenex-PSE, Nalex, Syn-Rx, Rymed, Respaire-60 SR, Nasabid, G-Phed, Respaire-120 SR, Guaibid D, Guaifed, Nalex Jr, G-Phed- PD, Sinufed Timecelles, Versacaps, Guaivent PD, Guaibid D Pediatric, Guaifed-PD, Pseudocot-G, Zephrex, Nasatab LA, Eudal SR, Medent LD, Sudal 60/500, Maxifed-G, Tuss-LA, Stamoist E, V-Dec-M, Deconsal LA, D-Feda II, Guaifenex PSE 60, Demibid II, Guiadrine II, Iosal II, Guiatex II, Guiadrine II SR, Defen-LA, Respa-1st, Decongest II, Desal II, Deco-D, GP 500, Guaifed-PSE, Pan-Mist LA, Abletex-PSE, Guiadrine PSE 120, Duratuss, Guai-Vent/PSE, Guaifenex PSE 120, Hi Tex PSE, Guiatex PSE, Guai Sudo, Guaipax PSE, Iotex PSE, Ami-Tex PSE, Pseudo-G/PSI, Zaptec PSE, Ru Tuss DE, Robitussin PE, Guaifenex RX, Guaitab, Biotuss PE, Guiatuss PE, Mastussin PE, Mytussin PE, Q-Tussin PE, Robichem PE, T-Tussin PE, Tusscidin PE, Tussin PE, Sinufed, Venbid TR, Degen II, Pseudoephedrine-GuaiFENesin, Robafen PE, Guaivent, Altarussin PE, S-Pack, Sudafed Non Drying Sinus, Congestac, Uni Tussin PE, Humibid GC, Med-RX, Nasabid SR, Panmist LA, Panmist JR, H 9600 SR, Pseudovent, Pseudovent Ped, Duratuss GP, Aquatab D, Guaifenex GP, Dynex, Profen II, Profen Forte, Durasal II, Miraphen PSE, Guiadrine PSE, Guiatex II SR, We Mist LA, Triaminic Chest Congestion, Coldmist, Aquatab D Dose Pack, Drituss GP, We Mist II LA, Panmist-S, Pseudo GG, Coldmist LA, Coldmist Jr, Sudal SR, Pseudo Max, Pseudovent 400, Levall G, Guaifenex PSE 80, Pseudatex, Touro LA-LD, Guaifenex PSE 85, Poly-Vent, Jr, Nomuc-PE, Ambi 60/580, Ambi 80/780, Ambi 60/1000, Pseudo GG TR, Ru-Tuss Jr, ExeFen, SudaTex-G, Medent-LDI, Ambifed, Tenar PSE, ExeFen-IR, Mucus Relief D, Mardrops-EX, Triaminic Chest/Nasal

Synonyms: n.a.

What is Entex PSE?