Azelastine and fluticasone nasal and Tice BCG Live (for intravesical use)
Determining the interaction of Azelastine and fluticasone nasal and Tice BCG Live (for intravesical use) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.GENERALLY AVOID: Administration of intravesical BCG during immunosuppressive corticosteroid therapy may be associated with a risk of disseminated infection due to enhanced replication of the BCG strain of Mycobacterium bovis in the presence of diminished immune competence. Deaths have been reported as a result of systemic BCG infection and sepsis. Patients may be immunosuppressed if they have recently received or are receiving high dosages of corticosteroids or adrenocorticotropic agents (e.g., greater than 10 mg/day or 1 mg/kg/day of prednisone or equivalent for more than 2 weeks), or long-term topical or inhaled corticosteroids. In addition, these patients may not develop an adequate immune response to BCG, which would reduce its anti-tumor efficacy. MANAGEMENT: In general, intravesical BCG should not be used in patients receiving immunosuppressive corticosteroid therapy. Patients who have been treated with topical or inhaled corticosteroids for a prolonged period should be evaluated to determine if they are immunosuppressed prior to receiving intravesical BCG. References Rawls WH, Lamm DL, Lowe BA, et al. "Fatal sepsis following intravesical bacillus Calmette-Guerin administration for bladder cancer." J Urol 144 (1990): 1328-30 Lamm DL, Stogdill VD, Stogdill BJ, Crispen RG "Complications of bacillus Calmette-Guerin immunotherapy in 1,278 patients with bladder cancer." J Urol 135 (1986): 272-4 Cerner Multum, Inc. "Australian Product Information." O 0 Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 "Product Information. Tice BCG Live (for intravesical use) (BCG)." Organon Pharmaceuticals, West Orange, NJ. View all 5 references
Professional:GENERALLY AVOID: Administration of intravesical BCG during immunosuppressive corticosteroid therapy may be associated with a risk of disseminated infection due to enhanced replication of the BCG strain of Mycobacterium bovis in the presence of diminished immune competence. Deaths have been reported as a result of systemic BCG infection and sepsis. Patients may be immunosuppressed if they have recently received or are receiving high dosages of corticosteroids or adrenocorticotropic agents (e.g., greater than 10 mg/day or 1 mg/kg/day of prednisone or equivalent for more than 2 weeks), or long-term topical or inhaled corticosteroids. In addition, these patients may not develop an adequate immune response to BCG, which would reduce its anti-tumor efficacy.
MANAGEMENT: In general, intravesical BCG should not be used in patients receiving immunosuppressive corticosteroid therapy. Patients who have been treated with topical or inhaled corticosteroids for a prolonged period should be evaluated to determine if they are immunosuppressed prior to receiving intravesical BCG.
- Rawls WH, Lamm DL, Lowe BA, et al. "Fatal sepsis following intravesical bacillus Calmette-Guerin administration for bladder cancer." J Urol 144 (1990): 1328-30
- Lamm DL, Stogdill VD, Stogdill BJ, Crispen RG "Complications of bacillus Calmette-Guerin immunotherapy in 1,278 patients with bladder cancer." J Urol 135 (1986): 272-4
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Tice BCG Live (for intravesical use) (BCG)." Organon Pharmaceuticals, West Orange, NJ.
Generic Name: azelastine / fluticasone nasal
Brand name: Dymista
Synonyms: Azelastine and Fluticasone
Generic Name: bcg
Brand name: Tice BCG Live, Tice BCG Vaccine, Theracys 3, TheraCys, BCG vaccine, Tice BCG
Synonyms: BCG intravesical, BCG (Intravesical)
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Azelastine and fluticasone nasal-Ticlid
- Azelastine and fluticasone nasal-Ticlopidine
- Azelastine and fluticasone nasal-Ticlopidine Hydrochloride
- Azelastine and fluticasone nasal-Ticon
- Azelastine and fluticasone nasal-Ticon oral/injection
- Azelastine and fluticasone nasal-Tigan
- Tice BCG Live (for intravesical use)-Azelastine Hydrochloride
- Tice BCG Live (for intravesical use)-Azelastine nasal
- Tice BCG Live (for intravesical use)-Azelastine ophthalmic
- Tice BCG Live (for intravesical use)-Azelastine Ophthalmic Solution
- Tice BCG Live (for intravesical use)-Azelex
- Tice BCG Live (for intravesical use)-Azelex Topical