Azelastine ophthalmic and Cimetidine Hydrochloride
Determining the interaction of Azelastine ophthalmic and Cimetidine Hydrochloride and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Cimetidine has been reported to increase the area under the concentration time curve of orally administered azelastine by 65%. The mechanism of the interaction is unknown, but may be related to inhibition by cimetidine of hepatic enzymes responsible for the metabolism of azelastine. The importance of this interaction with intranasal or ophthalmic azelastine is unknown. Patients requiring this combination should be observed for excessive azelastine adverse effects. Ranitidine has not been shown to affect the pharmacokinetic disposition of azelastine and may provide an alternative to cimetidine.
- "Product Information. Astelin (azelastine)." Carter Products, Cranbury, NJ.
Generic Name: azelastine ophthalmic
Brand name: Optivar
Synonyms: Azelastine (Ophthalmic)
Generic Name: cimetidine
Brand name: Tagamet HB, Tagamet
Synonyms: Cimetidine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Azelastine ophthalmic-Cimetidine Injection
- Azelastine ophthalmic-Cimetidine Oral Solution
- Azelastine ophthalmic-Cimetidine Sodium Chloride
- Azelastine ophthalmic-Cimetidine Tablets
- Azelastine ophthalmic-Cimzia
- Azelastine ophthalmic-Cimzia (Certolizumab Prefilled Syringes)
- Cimetidine Hydrochloride-Azelastine Ophthalmic Solution
- Cimetidine Hydrochloride-Azelex
- Cimetidine Hydrochloride-Azelex Topical
- Cimetidine Hydrochloride-Azesco
- Cimetidine Hydrochloride-Azilect
- Cimetidine Hydrochloride-Azilsartan