Azilect and Paxil

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using rasagiline together with PARoxetine is not recommended. Combining these medications can increase the risk of a rare but serious condition called the serotonin syndrome, which may include symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea. Severe cases may result in coma and even death. In general, you should wait at least 14 days after stopping rasagiline before you start treatment with PARoxetine. Conversely, if you have recently been on PARoxetine and are now starting treatment with rasagiline, you should check with your doctor or pharmacist to see how long you should wait before it is safe for you to use rasagiline, as some antidepressants can take a while to clear from your body. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: By inhibiting serotonin metabolism, monoamine oxidase inhibitors (MAOIs) may potentiate the pharmacologic activity of selective serotonin reuptake inhibitors (SSRIs) and increase the risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A and 2A receptors. Symptoms of the serotonin syndrome may include mental status changes such as irritability, altered consciousness, confusion, hallucinations, and coma; autonomic dysfunction such as tachycardia, hyperthermia, diaphoresis, shivering, blood pressure lability, and mydriasis; neuromuscular abnormalities such as hyperreflexia, myoclonus, tremor, rigidity, and ataxia; and gastrointestinal symptoms such as abdominal cramping, nausea, vomiting, and diarrhea. The extent to which rasagiline, a selective MAO-B inhibitor, may interact with SSRIs is unknown. In rasagiline clinical trials, concomitant use of fluoxetine or fluvoxamine was prohibited, although the use of some antidepressants, including citalopram (20 mg/daily), sertraline (100 mg/daily) and paroxetine (30 mg/daily), was allowed. A total of 141 rasagiline-treated patients were exposed to SSRIs in these trials. However, the exposure, both in dosage and number of subjects, was not adequate to rule out the possibility of a potential interaction. In the postmarketing period, non-fatal cases of serotonin syndrome have been reported in patients receiving rasagiline in combination with antidepressants.

MANAGEMENT: In general, SSRIs should not be used concurrently with MAOIs or other agents that possess MAOI activity. At least 14 days should elapse between discontinuation of MAOI therapy and initiation of treatment with SSRIs, and vice versa. Due to the long half-life of fluoxetine and its active metabolite, norfluoxetine, a washout period of 5 weeks minimum is recommended when switching from fluoxetine to an MAOI. Similarly, a washout period of 3 weeks is recommended when switching from vortioxetine to an MAOI.

Azilect

Generic Name: rasagiline

Brand name: Azilect

Synonyms: n.a.

What is Azilect?

Paxil

Generic Name: paroxetine

Brand name: Paxil, Brisdelle, Paxil CR, Pexeva

Synonyms: n.a.

What is Paxil?