Azilsartan and Meperidine and Promethazine Capsules
Determining the interaction of Azilsartan and Meperidine and Promethazine Capsules and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using meperidine together with promethazine may increase side effects such as drowsiness, dizziness, lightheadedness, confusion, depression, low blood pressure, slow or shallow breathing, and impairment in thinking, judgment, and motor coordination. Occasionally, severe reactions may result in coma and even death. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. You should avoid the use of alcohol while being treated with these medications. Also avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSE: The central nervous system and respiratory depressant effects of meperidine may be potentiated by concomitant use of other agents with CNS depressant effects. An increased risk of serious adverse reactions such as respiratory depression, hypotension, profound sedation, syncope, coma, and even death should be considered, particularly in elderly or debilitated patients.
MANAGEMENT: Caution and dosage adjustments are advisable when meperidine is used in combination with other narcotic analgesics, general anesthetics, phenothiazines, sedative-hypnotics, tranquilizers, tricyclic antidepressants, or other CNS depressants such as alcohol. A lower dosage of meperidine should be considered initially, then titrated carefully according to pain level and clinical response. Meperidine dosage reductions of 25% to 50% have been recommended for patients receiving phenothiazines and other tranquilizers. Patients should be advised to avoid rising abruptly from a sitting or recumbent position, and to notify their physician if they experience dizziness, lightheadedness, orthostasis, syncope, tachycardia, or excessive CNS effects that interfere with their normal activities. Patients should also avoid driving or operating hazardous machinery until they know how these medications affect them.
- Lambertsen CJ, Wendel H, Longenhagen JB "The separate and combined respiratory effects of chlorpromazine and meperidine in normal men controlled at 46 mm Hg alveolar pCO2." J Pharmacol Exp Ther 131 (1961): 381-93
- "Product Information. Demerol (meperidine)." Sanofi Winthrop Pharmaceuticals, New York, NY.
- Hoffman JC, Smith TC "The respiratory effects of meperidine and propiomazine in man." Anesthesiology 32 (1970): 325-31
- Stambaugh JE, Wainer IW "Drug interaction: meperidine and chlorpromazine, a toxic combination." J Clin Pharmacol 21 (1981): 140-6
- "Product Information. Meperidine Hydrochloride Injection, USP (meperidine)" Astra-Zeneca Pharmaceuticals, Wilmington, DE.
Generic Name: azilsartan medoxomil
Brand name: Edarbi
Synonyms: Edarbi
Generic Name: meperidine / promethazine
Brand name:
Synonyms: Meperidine and Promethazine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Azilsartan-Meperidine Hydrochloride
- Azilsartan-Meperidine Injection
- Azilsartan-Meperidine Syrup and Oral Solution
- Azilsartan-Meperidine Tablets
- Azilsartan-Meperitab
- Azilsartan-Mephobarbital
- Meperidine and Promethazine Capsules-Azilsartan and chlorthalidone
- Meperidine and Promethazine Capsules-Azilsartan Kamedoxomil
- Meperidine and Promethazine Capsules-Azilsartan medoxomil
- Meperidine and Promethazine Capsules-Azithromycin
- Meperidine and Promethazine Capsules-Azithromycin (Systemic)
- Meperidine and Promethazine Capsules-Azithromycin 3 Day Dose Pack