Azithromycin Dihydrate and Typhoid vaccine, live
Determining the interaction of Azithromycin Dihydrate and Typhoid vaccine, live and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:If you are currently being treated with azithromycin or have been treated within the last 3 days, you should talk to your doctor before taking typhoid vaccine, live. Antibiotics like azithromycin can reduce the activity of the vaccine. To ensure adequate vaccine response, you should generally not take typhoid vaccine, live until at least 3 days after you complete your azithromycin therapy. If you have started taking typhoid vaccine, live, it would be best to wait at least 3 days after the last dose of vaccine before using azithromycin. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: The use of live, attenuated oral typhoid vaccine with antibacterial sulfonamides or other antibiotics may result in a diminished immunologic response to the vaccine. Some antibiotics may be active against the vaccine strain of Salmonella typhi (Ty21a), thereby preventing a sufficient degree of multiplication to occur in order to induce a protective immune response. Several antimalarial drugs such as chloroquine, mefloquine, and pyrimethamine-sulfadoxine also possess antibacterial activity, but concomitant administration did not significantly reduce immune response to the vaccine or compromise its efficacy in healthy adult study subjects. By contrast, concomitant administration of proguanil did cause a significant decrease in the immune response rate. The effects of other antimalarial agents have not been studied.
MANAGEMENT: Live, attenuated oral typhoid vaccine should not be administered during and for at least 3 days before and after treatment with antibacterial sulfonamides or other antibiotics. A longer interval should be considered following treatment with long-acting antibiotics (e.g., azithromycin). If malaria prophylaxis is needed, the same 3-day interval at the minimum should be observed between antimalarials and the vaccine. However, chloroquine, mefloquine, and pyrimethamine-sulfadoxine may be given concomitantly with the vaccine. Alternatively, parenteral typhoid vaccine (typhoid Vi polysaccharide vaccine) may be considered if coadministration with antibacterial agents is required.
- UK government "Typhoid. Available from: URL: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/148512/Green-Book-Chapter-33-dh_125348.pdf." ([cited 2014]):
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- CDC. Centers for Disease Control and Prevention "Typhoid & Paratyphoid Fever. Available from: URL: http://wwwnc.cdc.gov/travel/yellowbook/2014/chapter-3-infectious-diseases-related-to-travel/typhoid-and-paratyphoid-fever." ([2013]):
- American Medical Association, Division of Drugs and Toxicology "Drug evaluations annual 1994." Chicago, IL: American Medical Association; (1994):
Generic Name: azithromycin
Brand name: AzaSite, Azithromycin 3 Day Dose Pack, Azithromycin 5 Day Dose Pack, Zithromax, Zithromax Tri-Pak, Zithromax Z-Pak, Zmax, Zithromax IV
Synonyms: Azithromycin, Azithromycin (Systemic)
Generic Name: typhoid vaccine, live
Brand name: Vivotif Berna
Synonyms: Typhoid vaccine (live), oral, Typhoid Vaccine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Azithromycin Dihydrate-Typhoid vi polysaccharide vaccine Intramuscular
- Azithromycin Dihydrate-Tysabri
- Azithromycin Dihydrate-Tyvaso
- Azithromycin Dihydrate-Tyzeka
- Azithromycin Dihydrate-Tyzine
- Typhoid vaccine, live-Azithromycin Extended-Release Oral Suspension
- Typhoid vaccine, live-Azithromycin Injection
- Typhoid vaccine, live-Azithromycin Intravenous
- Typhoid vaccine, live-Azithromycin Oral Suspension
- Typhoid vaccine, live-Azithromycin Single-Dose Packet
- Typhoid vaccine, live-Azithromycin Tablets