Azithromycin (Systemic) and Unasyn
Determining the interaction of Azithromycin (Systemic) and Unasyn and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Although some in vitro data indicate synergism between macrolide antibiotics and penicillins, other in vitro data indicate antagonism. When these drugs are given together, neither has predictable therapeutic efficacy. Data are available for erythromycin, although theoretically this interaction could occur with any macrolide. Except for monitoring of the effectiveness of antibiotic therapy, no special precautions appear to be necessary.
- Strom J "Penicillin and erythromycin singly and in combination in scarlatina therapy and the interference between them." Antibiot Chemother 11 (1961): 694-7
- Cohn JR, Jungkind DL, Baker JS "In vitro antagonism by erythromycin of the bactericidal action of antimicrobial agents against common respiratory pathogens." Antimicrob Agents Chemother 18 (1980): 872-6
- Penn RL, Ward TT, Steigbigel RT "Effects of erythromycin in combination with penicillin, ampicillin, or gentamicin on the growth of listeria monocytogenes." Antimicrob Agents Chemother 22 (1982): 289-94
Generic Name: azithromycin
Brand name: AzaSite, Azithromycin 3 Day Dose Pack, Azithromycin 5 Day Dose Pack, Zithromax, Zithromax Tri-Pak, Zithromax Z-Pak, Zmax, Zithromax IV
Synonyms: Azithromycin
Generic Name: ampicillin / sulbactam
Brand name: Unasyn, Unasyn ADD-Vantage
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Azithromycin (Systemic)-Uni-Cenna
- Azithromycin (Systemic)-Unipen
- Azithromycin (Systemic)-Uniphyl
- Azithromycin (Systemic)-Uniretic
- Azithromycin (Systemic)-Unisom
- Azithromycin (Systemic)-Unisom Sleepgels Maximum Strength
- Unasyn-Azithromycin 3 Day Dose Pack
- Unasyn-Azithromycin 5 Day Dose Pack
- Unasyn-Azithromycin Dihydrate
- Unasyn-Azithromycin Extended-Release Oral Suspension
- Unasyn-Azithromycin Injection
- Unasyn-Azithromycin Intravenous