Azulfidine EN-tabs and Lanoxin Intravenous
Determining the interaction of Azulfidine EN-tabs and Lanoxin Intravenous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using sulfaSALAzine together with digoxin may decrease the effects of digoxin. Contact your doctor if your condition changes or if you experience worsening of your heart symptoms. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Sulfasalazine may decrease the gastrointestinal absorption of digoxin by an unknown mechanism. Bioavailability, serum levels, and effectiveness of digoxin may be decreased significantly.
MANAGEMENT: During coadministration, digoxin effectiveness and serum levels should be monitored. The clinician should consider alternating dosage schedules before resorting to an increase in digoxin dosage. Patients should be advised to notify their physician if they experience worsening of their heart symptoms.
- Juhl RP, Summers RW, Guillory JK, Blaug SM, Cheng FH, Brown DD "Effect of sulfasalazine on digoxin bioavailability." Clin Pharmacol Ther 20 (1976): 387-94
- Rodin SM, Johnson BF "Pharmacokinetic interactions with digoxin." Clin Pharmacokinet 15 (1988): 227-44
Generic Name: sulfasalazine
Brand name: Azulfidine, Azulfidine EN-tabs, Sulfazine
Synonyms: Azulfidine EN Tablets
Generic Name: digoxin
Brand name: Lanoxin, Digitek, Digox, Lanoxicaps, Cardoxin
Synonyms: Lanoxin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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