Drug search by name

BACiiM and Plazomicin Intravenous

Determining the interaction of BACiiM and Plazomicin Intravenous and the possibility of their joint administration.

Check result:

BACiiM <> Plazomicin Intravenous

Relevance: 19.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using plazomicin together with bacitracin may increase the risk of serious side effects such as hearing loss, respiratory depression, and kidney problems. Patients who may be particularly susceptible include the elderly and those who are dehydrated or have preexisting kidney disease. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. Let your doctor know immediately if you experience hearing loss, ringing in the ears, vertigo, difficulty breathing, or signs and symptoms of kidney damage such as nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: The combination of a polypeptide antibiotic and an aminoglycoside may increase the risk of neurotoxicity, respiratory paralysis, and renal dysfunction. The mechanism of this interaction is not known, but may involve additive or synergistic effects.

MANAGEMENT: This combination should be avoided concurrently or sequentially. If coadministration is medically necessary, patients should be closely monitored for development of toxicity, including renal function tests, respiratory function, and vestibular and audiometric tests.

References

"Product Information. Arikayce (amikacin liposome)." Insmed Incorporated, Bridgewater, NJ.
Lindesmith LA, Baines RD Jr, Bigelow DB, Petty TL "Reversible respiratory paralysis associated with polymyxin therapy." Ann Intern Med 68 (1968): 318-27
Koch-Weser J, Sidel VW, Federman EB, Kanarek P, Finer DC, Eaton AE "Adverse effects of sodium colistimethate: manifestations and specific reaction rates during 317 courses of therapy." Ann Intern Med 72 (1970): 857-68
"Product Information. Garamycin (gentamicin)." Schering-Plough Corporation, Kenilworth, NJ.
"Product Information. Amikin (amikacin)." Bristol-Myers Squibb, Princeton, NJ.
"Product Information. Nebcin (tobramycin)." Lilly, Eli and Company, Indianapolis, IN.
Lee C, de Silva AJ "Interaction of neuromuscular blocking effects of neomycin and polymyxin B." Anesthesiology 50 (1979): 218-20

BACiiM

Generic Name: bacitracin

Brand name: Baci-IM, Baci-Rx

Synonyms: Baci-IM (injection)

What is BACiiM?

Plazomicin Intravenous

Generic Name: plazomicin

Brand name: Zemdri

Synonyms: Plazomicin

What is Plazomicin Intravenous?

+ Add a drug Remove all

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

The list of popular interactions