Bacillus of calmette and guerin vaccine, live Intradermal and Factor XIII (Human)

• Generic Name: bcg
• Dosage Forms: n.a.
• Other Brand Names:

  Tice BCG Live, Tice BCG Vaccine, Theracys 3, TheraCys, BCG vaccine, Tice BCG

Bacillus Calmette-Guérin (BCG) vaccine is given by injection to help prevent tuberculosis (TB). TB is a serious disease that can cause severe illness. It is spread by close contact with people who already have TB, such as people living in the same house. Some infected people do not appear to be sick, but they can still spread TB to others. BCG vaccine does not provide 100% protection. Therefore it is important to avoid people with TB, even if you have received the vaccine.

BCG vaccine is to be administered only by or under the direct supervision of a doctor.

• Generic Name: factor XIII
• Dosage Forms: n.a.
• Other Brand Names: Corifact, Tretten

Routine prophylaxis and perioperative management of bleeding in patients with congenital factor XIII deficiency; designated an orphan drug by FDA for treatment of congenital factor XIII deficiency.

Initial FDA-labeled use based on trough factor XIII levels (5–20%) as a surrogate measure of efficacy; clinical benefit (i.e., prevention of bleeding episodes) established in a postmarketing study.

Prophylactic therapy with factor XIII concentrates is recommended in all patients with severe (<1% factor XIII activity) deficiency; considered current standard of care.

Currently available factor XIII concentrates in the US include a plasma-derived (Corifact) and a recombinant (Tretten) preparation. Some experts recommend preferential use of recombinant preparations because of their potentially superior safety profile with respect to pathogen transmission. (See Risk of Transmissible Agents in Plasma-derived Preparations under Cautions.) When selecting an appropriate factor XIII preparation, consider characteristics of each clotting factor concentrate in addition to individual patient variables.

Has been used to treat acquired factor XIII deficiency associated with various diseases or other conditions.