Baclofen Intrathecal and Carbidopa, entacapone, and levodopa
Determining the interaction of Baclofen Intrathecal and Carbidopa, entacapone, and levodopa and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using levodopa together with baclofen may cause some unpleasant side effects including hallucination, confusion, headache, nausea, vomiting, unsteadiness, and a worsening of parkinsonian symptoms. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of levodopa and oral baclofen has rarely resulted in hallucinations, mental confusion, headache, nausea, and exacerbation of parkinsonian symptoms. The mechanism is unknown.
MANAGEMENT: If concurrent use cannot be avoided, monitoring for mental status changes and worsening of symptoms is advisable.
- Skausig OB, Korsgaard S "Hallucinations and baclofen." Lancet 1 (1977): 1258
- Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: baclofen
Brand name: Lioresal Intrathecal, Gablofen, FIRST Baclofen, Lioresal, Ozobax
Synonyms: Baclofen
Generic Name: carbidopa / entacapone / levodopa
Brand name: Stalevo 100, Stalevo 125, Stalevo 150, Stalevo 200, Stalevo 50, Stalevo 75, Stalevo
Synonyms: Levodopa, Carbidopa, and Entacapone
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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