Bacteriostatic Sodium Chloride and Cubicin, Cubicin RF

• Generic Name: sodium chloride
• Dosage Forms: injection, solution
• Other Brand Names:

  BD PosiFlush SF, Normal Saline flush, Swabflush, Syrex, Thermoject, Tip-Lok Diluent, Hyper-Sal, Nebusal, Sodium chloride, Inhalation, HyperSal, Nebusal, PulmoSal, Altachlore, Muro 128, Sochlor, Adsorbonac, AK-NaCl

Maintenance or replacement of sodium chloride and water for hydration.

Prevention of muscle cramps and heat prostration secondary to fluid loss from excessive perspiration during exposure to high temperatures.

Prevention or treatment of deficiencies of sodium and chloride ions (e.g., caused by excessive diuresis or excessive salt restriction).

Extracellular fluid replacement (isotonic [0.9%] sodium chloride injection).

Management of metabolic alkalosis in the presence of fluid loss and mild sodium depletion (0.9% sodium chloride injection).

Management of severe sodium chloride depletion (e.g., presence of heart failure, renal impairment, during surgery, postoperatively) when rapid electrolyte restoration is essential (hypertonic [3 or 5%] sodium chloride injection).

Management of hyponatremia and hypochloremia resulting from administration of sodium-free fluids during fluid and electrolyte therapy (3 or 5% sodium chloride injection).

Management of extreme dilution of extracellular fluid following excessive water intake (e.g., resulting from multiple enemas or perfusion of irrigating solutions into open venous sinuses during transurethral prostatic resections) (3 or 5% sodium chloride injection).

Emergency treatment of severe sodium chloride depletion resulting from excessive sweating, vomiting, diarrhea, and other conditions (3 or 5% sodium chloride injection).

In general, isotonic sodium chloride solutions are used for parenteral replacement of chloride losses equal to or exceeding sodium losses; hypotonic sodium chloride solutions are used for parenteral maintenance of hydration requirements when only small quantities of salt are desired; hypertonic sodium chloride solutions are used for repletion in severe salt depletion syndrome.

Management of hyperosmolar diabetes (hypotonic [0.45%] sodium chloride injection).

Assessment of renal function status (0.45% sodium chloride injection).

Priming fluid for hemodialysis procedures (0.9% sodium chloride injection).

Initiate and terminate blood transfusions without hemolyzing RBCs (0.9% isotonic sodium chloride injection).

Pharmaceutical aid, diluent, and delivery system for the infusion of compatible drug additives.

Measurement of cardiac output by the thermodilution method (0.9% sodium chloride injection as Thermoject system).

Inhalation via nebulization, dilution of compatible drugs for nebulization, and tracheal lavage and irrigation (0.9% sodium chloride inhalation solution).

An inhalation for cystic fibrosis patients to produce a sustained acceleration of mucus clearance and improve lung function (7% sodium chloride solution).

• Generic Name: daptomycin
• Dosage Forms: n.a.
• Other Brand Names: Cubicin, Cubicin RF

Treatment of complicated skin and skin structure infections caused by susceptible Staphylococcus aureus (including methicillin-resistant S. aureus [MRSA; also known as oxacillin-resistant S. aureus or ORSA]), Streptococcus pyogenes (group A β-hemolytic streptococci, GAS), S. agalactiae (group B streptococci, GBS), S. dysgalactiae subsp. equisimilis, and Enterococcus faecalis (vancomycin-susceptible strains only).

Bacteremia and Endocarditis

Treatment of bacteremia (blood stream infection) caused by susceptible S. aureus (including MRSA).

Also used for treatment of S. aureus bacteremia in patients with right-sided infective endocarditis. Efficacy not established in patients with left-sided infective endocarditis caused by S. aureus; limited data suggest a poor outcome in such patients despite daptomycin treatment.

Not studied in patients with prosthetic valve endocarditis.