Bacteriostatic Sodium Chloride and Dextromethorphan Hydrobromide and Quinidine Sulfate

• Generic Name: sodium chloride
• Dosage Forms: injection, solution
• Other Brand Names:

  BD PosiFlush SF, Normal Saline flush, Swabflush, Syrex, Thermoject, Tip-Lok Diluent, Hyper-Sal, Nebusal, Sodium chloride, Inhalation, HyperSal, Nebusal, PulmoSal, Altachlore, Muro 128, Sochlor, Adsorbonac, AK-NaCl

Maintenance or replacement of sodium chloride and water for hydration.

Prevention of muscle cramps and heat prostration secondary to fluid loss from excessive perspiration during exposure to high temperatures.

Prevention or treatment of deficiencies of sodium and chloride ions (e.g., caused by excessive diuresis or excessive salt restriction).

Extracellular fluid replacement (isotonic [0.9%] sodium chloride injection).

Management of metabolic alkalosis in the presence of fluid loss and mild sodium depletion (0.9% sodium chloride injection).

Management of severe sodium chloride depletion (e.g., presence of heart failure, renal impairment, during surgery, postoperatively) when rapid electrolyte restoration is essential (hypertonic [3 or 5%] sodium chloride injection).

Management of hyponatremia and hypochloremia resulting from administration of sodium-free fluids during fluid and electrolyte therapy (3 or 5% sodium chloride injection).

Management of extreme dilution of extracellular fluid following excessive water intake (e.g., resulting from multiple enemas or perfusion of irrigating solutions into open venous sinuses during transurethral prostatic resections) (3 or 5% sodium chloride injection).

Emergency treatment of severe sodium chloride depletion resulting from excessive sweating, vomiting, diarrhea, and other conditions (3 or 5% sodium chloride injection).

In general, isotonic sodium chloride solutions are used for parenteral replacement of chloride losses equal to or exceeding sodium losses; hypotonic sodium chloride solutions are used for parenteral maintenance of hydration requirements when only small quantities of salt are desired; hypertonic sodium chloride solutions are used for repletion in severe salt depletion syndrome.

Management of hyperosmolar diabetes (hypotonic [0.45%] sodium chloride injection).

Assessment of renal function status (0.45% sodium chloride injection).

Priming fluid for hemodialysis procedures (0.9% sodium chloride injection).

Initiate and terminate blood transfusions without hemolyzing RBCs (0.9% isotonic sodium chloride injection).

Pharmaceutical aid, diluent, and delivery system for the infusion of compatible drug additives.

Measurement of cardiac output by the thermodilution method (0.9% sodium chloride injection as Thermoject system).

Inhalation via nebulization, dilution of compatible drugs for nebulization, and tracheal lavage and irrigation (0.9% sodium chloride inhalation solution).

An inhalation for cystic fibrosis patients to produce a sustained acceleration of mucus clearance and improve lung function (7% sodium chloride solution).

• Generic Name: dextromethorphan / quinidine
• Dosage Forms: n.a.
• Other Brand Names: Nuedexta

The fixed combination of dextromethorphan hydrobromide and quinidine sulfate (dextromethorphan/quinidine; Nuedexta) is used in the treatment of PBA.

PBA occurs secondary to various otherwise unrelated neurologic conditions (e.g., amyotrophic lateral sclerosis [ALS], multiple sclerosis [MS], dementia of the Alzheimer's type [Alzheimer's disease] or other dementia, parkinsonian syndrome, stroke, traumatic brain injury) and is characterized by involuntary, sudden, uncontrollable, and frequent episodes of laughing and/or crying. PBA episodes typically occur out of proportion or incongruent to the underlying emotional state.

Studies supporting efficacy in PBA were conducted in patients with underlying ALS or MS.

Safety and efficacy in the treatment of other common types of emotional lability (e.g., those occurring in patients with Alzheimer's disease and other dementias) not established.