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Bactrim and Imuran

Determining the interaction of Bactrim and Imuran and the possibility of their joint administration.

Check result:

Bactrim <> Imuran

Relevance: 17.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using azaTHIOprine together with trimethoprim may increase your risk of infections. Call your doctor at once if you have a fever, chills, sore throat, body aches, weakness, muscle pain, easy bruising or bleeding, mouth sores, pale stools, darkened urine, or severe nausea, vomiting, and diarrhea. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Even though the combination is used in clinical practice, the risk of bone marrow suppression may be increased when azathioprine or mercaptopurine is coadministered with trimethoprim or sulfamethoxazole-trimethoprim (co-trimoxazole). The risk may be increased when concurrent therapy is longer than 3 weeks. Thrombocytopenia and neutropenia have been reported; however, data have been conflicting. The mechanism is unknown, but may be related to additive myelosuppressive effects and hemodialysis-induced folate depletion.

MANAGEMENT: Close clinical and laboratory monitoring for the development of hematologic adverse effects is recommended both during and after discontinuation of therapy. Dosage adjustment of azathioprine or mercaptopurine may be considered if an interaction is suspected. Patients should be advised to promptly report symptoms such as chills, fever, malaise, sore throat, mouth sores, unusual fatigue, bruising, or bleeding.

References

Berg KJ, Gjellestad A, Nordby G, et al "Renal effects of trimethoprim in ciclosporin- and azathioprine-treated kidney-allografted patients." Nephron 53 (1989): 218-22
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Imuran (azathioprine)." Glaxo Wellcome, Research Triangle Park, NC.
Bailey RR "Leukopenia due to a trimethoprim-azathioprine interaction." N Z Med J 97 (1984): 739
Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."

Bactrim

Generic Name: sulfamethoxazole / trimethoprim

Brand name: Bactrim, Bactrim DS, Bactrim IV, Septra IV, SMZ-TMP DS, Sulfatrim Pediatric, Septra, Sulfatrim, Bethaprim, Cotrim, Uroplus, Uroplus DS, Cotrim DS, Bactrim Pediatric, Bethaprim Pediatric, Sulfatrim Suspension, Cotrim Pediatric, Septra DS

Synonyms: n.a.

What is Bactrim?

Imuran

Generic Name: azathioprine

Brand name: Azasan, Imuran

Synonyms: n.a.

What is Imuran?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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