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Bactrim and Novocain

Determining the interaction of Bactrim and Novocain and the possibility of their joint administration.

Check result:
Bactrim <> Novocain
Relevance: 17.07.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using procaine together with sulfamethoxazole. Procaine may decrease the effects of sulfamethoxazole. Ask your doctor to consider an alternative to procaine. If your doctor prescribes these medications together, you may need a dose adjustment to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Ester-type anesthetics are hydrolyzed to paraaminobenzoic acid which may inhibit the action of sulfonamides.

MANAGEMENT: The administration ester-type anesthetics to patients who are on sulfonamides should generally be avoided. Amide-type anesthetics are not expected to interact and may be considered as alternatives (e.g., bupivacaine, levobupivacaine, lidocaine, mepivacaine).

References
  • Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Bactrim

Generic Name: sulfamethoxazole / trimethoprim

Brand name: Bactrim, Bactrim DS, Bactrim IV, Septra IV, SMZ-TMP DS, Sulfatrim Pediatric, Septra, Sulfatrim, Bethaprim, Cotrim, Uroplus, Uroplus DS, Cotrim DS, Bactrim Pediatric, Bethaprim Pediatric, Sulfatrim Suspension, Cotrim Pediatric, Septra DS

Synonyms: n.a.

Novocain

Generic Name: procaine

Brand name: Novocain

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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Disease interaction