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Balcoltra and Zonalon

Determining the interaction of Balcoltra and Zonalon and the possibility of their joint administration.

Check result:

Balcoltra <> Zonalon

Relevance: 06.09.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

The bioavailability and serum concentration of tricyclic antidepressants may be increased in women taking oral contraceptives. The mechanism may be related to inhibition of the hepatic metabolism of tricyclics. The clinical significance of this interaction is unknown.

References

Edelbroek PM, Zitman FG, Knoppert-van der Klein EA, van Putten PM, de Wolff FA "Therapeutic drug monitoring of amitriptyline: impact of age, smoking and contraceptives on drug and metabolite levels in bulimic women." Clin Chim Acta 165 (1987): 177-87
Khurana RC "Estrogen-imipramine interaction." JAMA 222 (1972): 702-3
Somani SM, Khurana RC "Mechanism of estrogen-imipramine interaction." JAMA 223 (1973): 560
Prange AJ, Wilson IC, Alltop LB "Estrogen may well affect response to antidepressant." JAMA 219 (1972): 143-4
Abernethy DR, Greenblatt DJ, Shader RI "Imipramine disposition in users of oral contraceptive steroids." Clin Pharmacol Ther 35 (1984): 792-7

Balcoltra

Generic Name: ethinyl estradiol / levonorgestrel

Brand name: Amethyst, Aviane, Balcoltra, Falmina, Levlen, Lillow, Orsythia, Vienva, Afirmelle, Altavera, Amethia, Amethia Lo, Ashlyna, Aubra, Aubra EQ, Ayuna, Camrese, Camrese Lo, Chateal, Chateal EQ, Daysee, Delyla, Enpresse-28, FaLessa, Fayosim, Introvale, Jolessa, Kurvelo, Larissia, Lessina, Levonest, Levora 015/30, LoSeasonique, Lutera, Marlissa, Myzilra, Portia-28, Quartette, Quasense, Rivelsa, Seasonique, Setlakin, Simpesse, Sronyx, Trivora, Alesse, Enpresse, Levora, Lybrel, Nordette, Portia, Tri-Levlen, Triphasil-21, Triphasil-28, Trivora-28, Seasonale, Preven EC, Triphasil

Synonyms: n.a.

What is Balcoltra?

Zonalon

Generic Name: doxepin topical

Brand name: Prudoxin, Zonalon

Synonyms: n.a.

What is Zonalon?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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