Baloxavir marboxil and Calcium Carbonate Chewable Tablets
Determining the interaction of Baloxavir marboxil and Calcium Carbonate Chewable Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Baloxavir marboxil should not be taken together with calcium carbonate. Products that contain magnesium, aluminum, calcium, iron, and/or other minerals may interfere with the absorption of baloxavir marboxil and reduce its effectiveness. Talk to your doctor or pharmacist if you have questions on how to take baloxavir marboxil or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with polyvalent cation-containing products may decrease the plasma concentrations and therapeutic efficacy of baloxavir. The proposed mechanism is chelation of baloxavir by polyvalent cations, forming a complex that is poorly absorbed from the gastrointestinal tract. A significant decrease in baloxavir exposure was observed in monkeys when the prodrug, baloxavir marboxil, was coadministered with calcium, aluminum, magnesium, or iron. However, clinical data in humans are lacking.
MANAGEMENT: Concurrent administration of baloxavir marboxil with polyvalent cation-containing laxatives, antacids, or oral supplements (e.g., aluminum, calcium, iron, magnesium, selenium, zinc) should generally be avoided.
- "Product Information. Xofluza (baloxavir marboxil)." Genentech, South San Francisco, CA.
Generic Name: baloxavir marboxil
Brand name: Xofluza
Synonyms: Baloxavir Marboxil
Generic Name: calcium carbonate
Brand name: Calci-Chew, Oysco 500, Calci Mix, Os-Cal 500, Oyst Cal 500, Oyster Shell Calcium 500, Nephro Calci, Amitone, Dicarbosil, Equilet, Tums, Chooz, Tums E-X, Alkets, Titralac, Oyster Cal 500, Calcitab, Oyster Shell, Oyster Calcium, Super Calcium, Calcium Concentrate, Caltro, Oyster, Oyster Cal, Cal Oys, Alkums, Cal-Gest, Tums 500, Tums Ultra, Alka-Mints, Calcarb, Caltrate, Rolaids Sodium Free, Amilac, Calcium Oyster, Oyst Cal, Calcium Liquid Softgel, Mylanta Child, Maalox Quick Dissolve, Maalox Quick Dissolve Maximum Strength, Ultra Mylanta Calci Tabs, Extra Strength Mylanta Calci Tabs, Os-Cal, Surpass, Surpass Extra Strength, Icar Prenatal Chewable Calcium, Tums Extra Strength, Maalox Quick Dissolve Extra Strength, Calcium Oyster Shell, Maalox Antacid Barrier, Rolaids Soft Chew, Pepto Children's, Maalox Regular Strength, Maalox Children's, Tums Kids, Tums QuikPak, Calci-Mix, Alcalak, Tums Smoothies, Tums Chewy Bites, Tums Chewy Delights, Tums Sugar-Free, Cal-Mint, Calci Mix, OsCal 500
Synonyms: Calcium carbonate, Calcium Carbonate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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