Baloxavir marboxil and Choline Magnesium Trisalicylate Liquid
Determining the interaction of Baloxavir marboxil and Choline Magnesium Trisalicylate Liquid and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Baloxavir marboxil should not be taken together with magnesium salicylate. Products that contain magnesium, aluminum, calcium, iron, and/or other minerals may interfere with the absorption of baloxavir marboxil and reduce its effectiveness. Talk to your doctor or pharmacist if you have questions on how to take baloxavir marboxil or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with polyvalent cation-containing products may decrease the plasma concentrations and therapeutic efficacy of baloxavir. The proposed mechanism is chelation of baloxavir by polyvalent cations, forming a complex that is poorly absorbed from the gastrointestinal tract. A significant decrease in baloxavir exposure was observed in monkeys when the prodrug, baloxavir marboxil, was coadministered with calcium, aluminum, magnesium, or iron. However, clinical data in humans are lacking.
MANAGEMENT: Concurrent administration of baloxavir marboxil with polyvalent cation-containing laxatives, antacids, or oral supplements (e.g., aluminum, calcium, iron, magnesium, selenium, zinc) should generally be avoided.
- "Product Information. Xofluza (baloxavir marboxil)." Genentech, South San Francisco, CA.
Generic Name: baloxavir marboxil
Brand name: Xofluza
Synonyms: Baloxavir Marboxil
Generic Name: choline salicylate / magnesium salicylate
Brand name: Choline magnesium trisalicylate, Tricosal, Trilisate, CMT
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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