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Baloxavir marboxil and Magnesium amino acids chelate

Determining the interaction of Baloxavir marboxil and Magnesium amino acids chelate and the possibility of their joint administration.

Check result:

Baloxavir marboxil <> Magnesium amino acids chelate

Relevance: 02.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Baloxavir marboxil should not be taken together with magnesium amino acids chelate. Products that contain magnesium, aluminum, calcium, iron, and/or other minerals may interfere with the absorption of baloxavir marboxil and reduce its effectiveness. Talk to your doctor or pharmacist if you have questions on how to take baloxavir marboxil or other medications you are prescribed. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with polyvalent cation-containing products may decrease the plasma concentrations and therapeutic efficacy of baloxavir. The proposed mechanism is chelation of baloxavir by polyvalent cations, forming a complex that is poorly absorbed from the gastrointestinal tract. A significant decrease in baloxavir exposure was observed in monkeys when the prodrug, baloxavir marboxil, was coadministered with calcium, aluminum, magnesium, or iron. However, clinical data in humans are lacking.

MANAGEMENT: Concurrent administration of baloxavir marboxil with polyvalent cation-containing laxatives, antacids, or oral supplements (e.g., aluminum, calcium, iron, magnesium, selenium, zinc) should generally be avoided.

References

"Product Information. Xofluza (baloxavir marboxil)." Genentech, South San Francisco, CA.

Baloxavir marboxil

Generic Name: baloxavir marboxil

Brand name: Xofluza

Synonyms: Baloxavir Marboxil

What is Baloxavir marboxil?

Magnesium amino acids chelate

Generic Name: magnesium amino acids chelate

Brand name: Chelated Magnesium, MG Plus Protein, Balnetar, Denorex Extra Strength, DHS Tar Shampoo, Elta Tar, Ionil T, MG217 Medicated Tar, Neutrogena T/Gel, Oxipor VHC, Psoriasin, Scytera, Tarsum, Tegrin Medicated, Theraplex T, Coal Tar, Zetar, G-TAR, Zeprime Tar Emulsion, Ionil T Plus, Pentrax, Denorex, Estar, Betatar Gel, Fototar, Doak Tar, Therapeutic, Neutrogena T/Gel Extra Strength, Denorex Medicated Shampoo and Conditioner, Denorex Dry Scalp, MG217 Psoriasis, Doak Tar Oil, Neutrogena T/Derm, Pentrax Gold, T/Gel Conditioner, Tegrin Medicated Soap, Psorigel, Polytar, Doctar, Cutar, Reme-T, Tera Gel, Exorex, Polytar Mild, Psoriderm, Clinitar, Alphosyl, Alphosyl 2 in 1, Carbo-Dome, Coal Tar Strong, T/Gel, Doak Oil Forte, Amcal Anti Itch Bath Solution, Hamilton Formicare Skin Wash, Apha Keri Tar, Neutrogena T-Gel Conditioner, Orion Coal Tar, Linotar, Exorex Penetrating Emulsion Psoriasis Medication, Apha Keri Tar Gel, Linotar Gel 2, Linotar Gel 3, Hamilton Pine Tar with Menthol, Eczema Cream, Pinetarsol Tar, Resolve Itch Cleansing Gel, PC Tar, Anti-Dandruff, Psoriasin Advanced Treatment, Psoriatar

Synonyms: n.a.

What is Magnesium amino acids chelate?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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