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Balversa and Phenobarbital with Belladonna Alkaloids Elixir

Determining the interaction of Balversa and Phenobarbital with Belladonna Alkaloids Elixir and the possibility of their joint administration.

Check result:
Balversa <> Phenobarbital with Belladonna Alkaloids Elixir
Relevance: 26.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this interaction is not currently available.GENERALLY AVOID: Coadministration with potent inducers of CYP450 2C9 or 3A4 may decrease the plasma concentrations and therapeutic effects of erdafitinib. The mechanism is induction of CYP450 2C9- or 3A4-mediated metabolism of erdafitinib, which has been shown to be metabolized by these isoenzymes. MANAGEMENT: Concomitant use of erdafitinib with potent inducers of CYP450 2C9 or 3A4 should be avoided. References "Product Information. Balversa (erdafitinib)." Janssen Products, LP, Horsham, PA.

Professional:

GENERALLY AVOID: Coadministration with potent inducers of CYP450 2C9 or 3A4 may decrease the plasma concentrations and therapeutic effects of erdafitinib. The mechanism is induction of CYP450 2C9- or 3A4-mediated metabolism of erdafitinib, which has been shown to be metabolized by these isoenzymes.

MANAGEMENT: Concomitant use of erdafitinib with potent inducers of CYP450 2C9 or 3A4 should be avoided.

References
  • "Product Information. Balversa (erdafitinib)." Janssen Products, LP, Horsham, PA.
Balversa

Generic Name: erdafitinib

Brand name: Balversa

Synonyms: n.a.

Phenobarbital with Belladonna Alkaloids Elixir

Generic Name: atropine / hyoscyamine / phenobarbital / scopolamine

Brand name: Donnatal, D-Tal, Phenohytro, Chardonna-2, Hyosophen, Donnapine, Elixiral, Bellatal, Spasmolin, Haponal, Antispas, Barbidonna, Donnatal Extentabs, Antispasmodic, Bellalphen, Donnaphen, Spasquid, Alkabel-SR, Bellatal ER, Servira, PB-Hyos, Quadrapax, Phenobarbital with Belladonna Alkaloids

Synonyms: Belladonna alkaloids and phenobarbital, Hyoscyamine, Atropine, Scopolamine, and Phenobarbital

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.