Banzel (Rufinamide Oral Suspension) and Darunavir and Cobicistat
Determining the interaction of Banzel (Rufinamide Oral Suspension) and Darunavir and Cobicistat and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Rufinamide may decrease the blood levels of cobicistat, which may make the medication less effective in treating HIV infection. Contact your doctor if your condition worsens or you develop new infections during treatment with these medications. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with moderate or weak inducers of CYP450 3A4 may reduce the plasma concentrations of cobicistat, which is primarily metabolized by the isoenzyme. The clinical significance is unknown.
MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic antiretroviral drug levels, concomitant use of antiretroviral regimens containing cobicistat with these inducers should be avoided. Alternative treatment combinations that do not include metabolic inducers should be considered whenever possible. If concomitant use is required, close clinical and laboratory monitoring of antiretroviral response is recommended.
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- EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Smith DS, Fujimoto JM "Alterations produced by novobiocin during biliary excretion of morphine, morphine-3-glucuronide and other compounds." J Pharmacol Exp Ther 188 (1974): 504-15
- "Product Information. Tybost (cobicistat)." Gilead Sciences, Foster City, CA.
Generic Name: rufinamide
Brand name: Banzel
Synonyms: Banzel
Generic Name: cobicistat / darunavir
Brand name: Prezcobix
Synonyms: Cobicistat and darunavir
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Banzel (Rufinamide Oral Suspension)-Darunavir Oral Suspension
- Banzel (Rufinamide Oral Suspension)-Darunavir Tablets
- Banzel (Rufinamide Oral Suspension)-Darunavir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide
- Banzel (Rufinamide Oral Suspension)-Darunavir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide Fumarate
- Banzel (Rufinamide Oral Suspension)-Darvocet
- Banzel (Rufinamide Oral Suspension)-Darvocet A500
- Darunavir and Cobicistat-Banzel (Rufinamide Tablets)
- Darunavir and Cobicistat-Baqsimi
- Darunavir and Cobicistat-Baraclude
- Darunavir and Cobicistat-Baraclude (Entecavir Oral Solution)
- Darunavir and Cobicistat-Baraclude (Entecavir Tablets)
- Darunavir and Cobicistat-Baricitinib