Basaglar KwikPen and Cobimetinib Fumarate

• Generic Name: insulin glargine
• Dosage Forms: injection, solution
• Other Brand Names: Basaglar KwikPen, Lantus, Lantus Solostar Pen, Toujeo SoloStar, Lantus OptiClik Cartridge, Toujeo Max SoloStar, Lantus SoloStar

Basaglar KwikPen is a long-acting insulin that starts to work several hours after injection and keeps working evenly for 24 hours.

Basaglar KwikPen is used to improve blood sugar control in adults and children with diabetes mellitus. This medicine is used to treat type 1 or type 2 diabetes in adults, and type 1 diabetes children who are at least 6 years old.

Some brands of Basaglar KwikPen are for use only in adults. Carefully follow all instructions for the brand of insulin glargine you are using.

Basaglar KwikPen may also be used for purposes not listed in this medication guide.

• Generic Name: cobimetinib
• Dosage Forms: n.a.
• Other Brand Names: Cotellic

In combination with vemurafenib for treatment of unresectable or metastatic melanoma with b-Raf serine-threonine kinase (BRAF) V600E or V600K mutation (designated an orphan drug by FDA for this use).

FDA-approved in vitro diagnostic test (e.g., cobas 4800 BRAF V600 mutation test) required to confirm presence of BRAF V600E or V600K mutation prior to initiation of therapy.

Limited data suggest greater efficacy (longer progression-free and overall survival, higher objective response rates) in patients with BRAF inhibitor-naive disease versus those with disease progression during prior BRAF inhibitor therapy.