Baycadron and Telaprevir

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using telaprevir together with dexamethasone. Combining these medications may decrease the blood levels of telaprevir, which may reduce its effectiveness in treating hepatitis C. At the same time, telaprevir may cause the blood levels of dexamethasone to increase. You may be more likely to experience side effects of dexamethasone such as swelling, weight gain, high blood pressure, high blood glucose, muscle weakness, depression, acne, thinning skin, stretch marks, easy bruising, bone density loss, cataracts, menstrual irregularities, excessive growth of facial or body hair, and abnormal distribution of body fat, especially in the face, neck, back, and waist. Other side effects that may occur include decreased ability to fight infections, increased risk of developing infections, and inadequate response to stress such as infection, surgery, trauma, or a severe asthma attack. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with dexamethasone may decrease the plasma concentrations of the hepatitis C virus NS3/4A protease inhibitors, boceprevir and telaprevir. The proposed mechanism is dexamethasone induction of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of these and other protease inhibitors. The interaction has not been specifically studied with dexamethasone, but has been reported with the potent CYP450 3A4 inducer, rifampin. In 16 study subjects, administration of a single 750 mg dose of telaprevir during treatment with rifampin 600 mg daily for 7 days reduced the telaprevir peak plasma concentration (Cmax) and systemic exposure (AUC) by an average of 86% and 92%, respectively, compared to administration alone. Conversely, boceprevir and telaprevir are potent inhibitors of CYP450 3A4 and may theoretically increase the plasma concentrations of dexamethasone, which is a substrate of the isoenzyme.

MANAGEMENT: Given the risk of reduced viral susceptibility and resistance development associated with subtherapeutic drug levels, concomitant use of boceprevir or telaprevir with dexamethasone should be avoided if possible. Otherwise, close clinical monitoring of the virologic response is advised. In addition, patients may experience increased systemic glucocorticoid effects and should be monitored for signs and symptoms of hypercorticism such as acne, striae, thinning of the skin, easy bruising, moon facies, dorsocervical "buffalo" hump, truncal obesity, increased appetite, acute weight gain, edema, hypertension, hirsutism, hyperhidrosis, proximal muscle wasting and weakness, glucose intolerance, exacerbation of preexisting diabetes, depression, and menstrual disorders. Other systemic glucocorticoid effects may include adrenal suppression, immunosuppression, posterior subcapsular cataracts, glaucoma, and bone loss. Dosage reduction for dexamethasone may be required.

Baycadron

Generic Name: dexamethasone

Brand name: Baycadron, Dexamethasone Intensol, DexPak 10 Day Taperpak, DexPak 13 DayTaperpak, DexPak 6 DayTaperpak, De-Sone LA, Dexacen-4, Dexasone, Dexasone LA, Solurex, Solurex LA, Decadron, DexPak, TaperDex, Zema-Pak, ZoDex, Zonacort

Synonyms: n.a.

What is Baycadron?

Telaprevir

Generic Name: telaprevir

Brand name: Incivek

Synonyms: Telaprevir (Oral)

What is Telaprevir?