Baycol and Novo-Cholamine Light
Determining the interaction of Baycol and Novo-Cholamine Light and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using cholestyramine together with cerivastatin may decrease the effects of cerivastatin. Cerivastatin should be administered several hours after cholestyramine. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: When administered concomitantly, cholestyramine decreases the bioavailability and peak plasma concentration of cerivastatin, most likely due to adsorption of the statin to the resin. In one study, the bioavailability was reduced by 21% and the peak plasma concentration by 41% under fasting conditions. Separating their administration times by 1 to 5 hours attenuated the effect, resulting in a reduction of 8% to 16% in the bioavailability, depending on length of time between the doses.
MANAGEMENT: If simultaneous therapy with both agents is desired, cerivastatin should be administered several hours after the bile acid binding resin.
- Muck W, Ritter W, Frey R, Wetzelsberger N, Lucker PW, Kuhlmann J "Influence of cholestyramine on the pharmacokinetics of cerivastatin." Int J Clin Pharmacol Ther 35 (1997): 1997
- "Product Information. Baycol (cerivastatin)." Bayer, West Haven, CT.
- Smith HT, Jokubaitis LA, Troendle AJ, Hwang DS, Robinson WT "Pharmacokinetics of fluvastatin and specific drug interactions." Am J Hypertens 6 (1993): s375-82
Generic Name: cholestyramine
Brand name: Cholestyramine Light, Prevalite, Questran, Questran Light, Locholest, Locholest Light, Questran Light Packets, Prevalite Packets, Questran Packets
Synonyms: Cholestyramine, Cholestyramine Resin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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