Bazedoxifene Acetate and Donepezil Hydrochloride

• Generic Name: bazedoxifene / conjugated estrogens
• Dosage Forms: n.a.
• Other Brand Names: Duavee

Bazedoxifene/conjugated estrogens in fixed combination: Prevention of osteoporosis in postmenopausal women with an intact uterus.

Not FDA-labeled for treatment of osteoporosis in postmenopausal women in the US. Bazedoxifene commercially available in other countries for this use.

Not recommended for prevention of osteoporosis in premenopausal women; safety and efficacy not established.

Bazedoxifene/conjugated estrogens in fixed combination: Management of moderate to severe vasomotor symptoms associated with menopause in women with an intact uterus.

• Generic Name: donepezil
• Dosage Forms: n.a.
• Other Brand Names: Aricept, Aricept ODT

Palliative treatment of mild to moderate dementia of the Alzheimer’s type (Alzheimer’s disease, presenile or senile dementia).

Comparative studies have not been performed to date, but donepezil does not share the hepatotoxic potential of tacrine and may be preferable to tacrine as a first-line treatment because it can be administered once daily and does not require regular monitoring of liver function.