BCG Vaccine (Immunization) and Fluticasone, umeclidinium, and vilanterol Inhalation
Determining the interaction of BCG Vaccine (Immunization) and Fluticasone, umeclidinium, and vilanterol Inhalation and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.GENERALLY AVOID: Administration of intravesical BCG during immunosuppressive corticosteroid therapy may be associated with a risk of disseminated infection due to enhanced replication of the BCG strain of Mycobacterium bovis in the presence of diminished immune competence. Deaths have been reported as a result of systemic BCG infection and sepsis. Patients may be immunosuppressed if they have recently received or are receiving high dosages of corticosteroids or adrenocorticotropic agents (e.g., greater than 10 mg/day or 1 mg/kg/day of prednisone or equivalent for more than 2 weeks), or long-term topical or inhaled corticosteroids. In addition, these patients may not develop an adequate immune response to BCG, which would reduce its anti-tumor efficacy. MANAGEMENT: In general, intravesical BCG should not be used in patients receiving immunosuppressive corticosteroid therapy. Patients who have been treated with topical or inhaled corticosteroids for a prolonged period should be evaluated to determine if they are immunosuppressed prior to receiving intravesical BCG. References Rawls WH, Lamm DL, Lowe BA, et al. "Fatal sepsis following intravesical bacillus Calmette-Guerin administration for bladder cancer." J Urol 144 (1990): 1328-30 Lamm DL, Stogdill VD, Stogdill BJ, Crispen RG "Complications of bacillus Calmette-Guerin immunotherapy in 1,278 patients with bladder cancer." J Urol 135 (1986): 272-4 Cerner Multum, Inc. "Australian Product Information." O 0 Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0 "Product Information. Tice BCG Live (for intravesical use) (BCG)." Organon Pharmaceuticals, West Orange, NJ. View all 5 references
Professional:GENERALLY AVOID: Administration of intravesical BCG during immunosuppressive corticosteroid therapy may be associated with a risk of disseminated infection due to enhanced replication of the BCG strain of Mycobacterium bovis in the presence of diminished immune competence. Deaths have been reported as a result of systemic BCG infection and sepsis. Patients may be immunosuppressed if they have recently received or are receiving high dosages of corticosteroids or adrenocorticotropic agents (e.g., greater than 10 mg/day or 1 mg/kg/day of prednisone or equivalent for more than 2 weeks), or long-term topical or inhaled corticosteroids. In addition, these patients may not develop an adequate immune response to BCG, which would reduce its anti-tumor efficacy.
MANAGEMENT: In general, intravesical BCG should not be used in patients receiving immunosuppressive corticosteroid therapy. Patients who have been treated with topical or inhaled corticosteroids for a prolonged period should be evaluated to determine if they are immunosuppressed prior to receiving intravesical BCG.
- Rawls WH, Lamm DL, Lowe BA, et al. "Fatal sepsis following intravesical bacillus Calmette-Guerin administration for bladder cancer." J Urol 144 (1990): 1328-30
- Lamm DL, Stogdill VD, Stogdill BJ, Crispen RG "Complications of bacillus Calmette-Guerin immunotherapy in 1,278 patients with bladder cancer." J Urol 135 (1986): 272-4
- Cerner Multum, Inc. "Australian Product Information." O 0
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Tice BCG Live (for intravesical use) (BCG)." Organon Pharmaceuticals, West Orange, NJ.
Generic Name: bcg
Brand name: Tice BCG Live, Tice BCG Vaccine, Theracys 3, TheraCys, BCG vaccine, Tice BCG
Synonyms: BCG intravesical, BCG (Intravesical)
Generic Name: fluticasone / umeclidinium / vilanterol
Brand name: Trelegy Ellipta
Synonyms: Fluticasone, umeclidinium, and vilanterol, Umeclidinium, and Vilanterol
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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- BCG Vaccine (Immunization)-Fluvastatin
- BCG Vaccine (Immunization)-Fluvastatin Capsules
- BCG Vaccine (Immunization)-Fluvastatin ER Tablets
- BCG Vaccine (Immunization)-Fluvastatin Extended-Release Tablets
- Fluticasone, umeclidinium, and vilanterol Inhalation-Bcg Vaccine Freeze Dried
- Fluticasone, umeclidinium, and vilanterol Inhalation-BD Glucose
- Fluticasone, umeclidinium, and vilanterol Inhalation-BD PosiFlush SF flush
- Fluticasone, umeclidinium, and vilanterol Inhalation-Be-Flex Plus
- Fluticasone, umeclidinium, and vilanterol Inhalation-Bebulin
- Fluticasone, umeclidinium, and vilanterol Inhalation-Bebulin VH