Bedaquiline Fumarate and Brilinta

• Generic Name: bedaquiline
• Dosage Forms: n.a.
• Other Brand Names: Sirturo

Treatment of pulmonary multidrug-resistant tuberculosis (i.e., caused by Mycobacterium tuberculosis resistant to isoniazid and rifampin) in conjunction with other antituberculosis agents.

Designated an orphan drug by FDA for use in treatment of active tuberculosis.

Use only when an effective treatment regimen for multidrug-resistant tuberculosis cannot otherwise be provided.

Safety and efficacy for treatment of drug-susceptible tuberculosis, extrapulmonary (e.g., CNS) tuberculosis, or latent tuberculosis infection not established; use not recommended.

Safety and efficacy for treatment of infections caused by nontuberculous mycobacteria (NTM) not established; use not recommended.

Patients with multidrug-resistant tuberculosis are at high risk for treatment failure and acquisition of further drug resistance. ATS, CDC, and IDSA recommend that such patients be referred to or that consultation be obtained from a specialized treatment center as identified by local or state health departments or the CDC.

• Generic Name: ticagrelor
• Dosage Forms: tablet
• Other Brand Names: Brilinta

Brilinta (ticagrelor) prevents platelets in your blood from sticking together to form an unwanted blood clot that could block an artery.

Brilinta is used together with aspirin to lower your risk of having a stroke, serious heart problems, or death after you've had a heart attack or severe chest pain (angina). It is also used to prevent blood clots in people that have had a stent placed in their heart.

Brilinta may also be used for purposes not listed in this medication guide.