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Bedaquiline Fumarate and Zorbtive

Determining the interaction of Bedaquiline Fumarate and Zorbtive and the possibility of their joint administration.

Check result:

Bedaquiline Fumarate <> Zorbtive

Relevance: 18.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Somatropin may reduce the blood levels and effects of bedaquiline. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of bedaquiline, which is primarily metabolized by CYP450 3A4 to the major N-monodesmethyl metabolite, M2. Because M2 is 4- to 6-fold less active than the parent drug in terms of antimycobacterial potency, the interaction may diminish the therapeutic effect of bedaquiline. In healthy volunteers, administration of a single 300 mg dose of bedaquiline in combination with the potent CYP450 3A4 inducer rifampin (600 mg once daily for 21 days) reduced bedaquiline systemic exposure (AUC) by 52% compared to administration alone. No data are available for use with other, less potent CYP450 3A4 or P-gp inducers.

MANAGEMENT: Caution is advised when bedaquiline is used in combination with inducers of CYP450 3A4 due to the potential for reduced antimycobacterial effect.

References

"Product Information. Sirturo (bedaquiline)." Janssen Pharmaceuticals, Titusville, NJ.

Bedaquiline Fumarate

Generic Name: bedaquiline

Brand name: Sirturo

Synonyms: Bedaquiline

What is Bedaquiline Fumarate?

Zorbtive

Generic Name: somatropin

Brand name: Genotropin, Genotropin Miniquick, Humatrope, Norditropin FlexPro Pen, Norditropin Nordiflex Pen, Nutropin AQ NuSpin 10, Nutropin AQ Pen 10 Cartridge, Omnitrope, Saizen, Serostim, Tev-Tropin, Zomacton, Zorbtive, Nutropin, Norditropin, Nutropin AQ, Nutropin Depot, Norditropin Cartridge, Saizen Click-Easy, Omnitrope Pen 5 Cartridge, HumatroPen, Omnitrope Pen 10 Cartridge, Nutropin AQ Pen 20 Cartridge, Nutropin AQ NuSpin 5, Nutropin AQ NuSpin 20, Saizen Kit

Synonyms: n.a.

What is Zorbtive?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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