Beleodaq Injection and Pentobarbital Sodium

• Generic Name: belinostat
• Dosage Forms: injection, powder, lyophilized, for solution
• Other Brand Names: Beleodaq

Belinostat is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Belinostat is used to treat peripheral T-cell lymphoma that has relapsed or has not responded to other treatments.

Belinostat was approved by the US Food and Drug Administration (FDA) on an "accelerated" basis. In clinical studies, non-small cell lung tumors responded to belinostat. However, it has not been shown that belinostat can improve symptoms or lengthen survival time.

Belinostat may also be used for purposes not listed in this medication guide.

• Generic Name: pentobarbital
• Dosage Forms: n.a.
• Other Brand Names:

  Nembutal Sodium, Nembutal

Short-term treatment of insomnia (i.e., ≤2 weeks duration); decreased effectiveness for sleep induction and maintenance after 2 weeks.

Has been used for routine sedation. However, barbiturates used infrequently for this indication since there are few clinical situations in which oral barbiturates provide a safety or efficacy advantage over nonbarbiturate sedatives/hypnotics.

Preoperatively, to produce sedation and relieve anxiety.

Provide basal hypnosis for general, spinal, or regional anesthesia, or to facilitate intubation procedures.

Alternate therapy to control status epilepticus or acute seizure episodes resulting from meningitis, poisons, eclampsia, alcohol withdrawal, tetanus, or chorea.

IV diazepam generally considered drug of choice for termination of status epilepticus.

Withdrawal of barbiturate or nonbarbiturate hypnotics in physically dependent patients.

Has been used to control acute episodes of agitated behavior in psychoses; however, little value in long-term management of psychoses.

Has been used in high doses to induce coma in the management of cerebral ischemia and increased intracranial pressure associated with head trauma, stroke, Reye’s syndrome, cardiac arrest, asphyxiation, or drowning.

Has been used to ameliorate or prevent sequelae associated with cerebral ischemia during neurosurgical procedures that require long periods of cerebral hypoxia.