Belladonna alkaloids and phenobarbital and Emflaza (Deflazacort Tablets)
Determining the interaction of Belladonna alkaloids and phenobarbital and Emflaza (Deflazacort Tablets) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:PHENobarbital may significantly reduce the blood levels of deflazacort, which may make the medication less effective in treating your condition. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Coadministration with potent or moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of 21-desdeflazacort, the active metabolite of deflazacort that is formed by esterases after oral administration and further metabolized by CYP450 3A4 to several inactive metabolites. According to the product labeling, when deflazacort was administered following multiple doses of rifampin, a strong CYP450 3A4 inducer, mean total exposure to 21-desdeflazacort decreased by approximately 95% compared to administration of deflazacort alone.
MANAGEMENT: Concomitant use of deflazacort with potent or moderate CYP450 3A4 inducers should generally be avoided.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: atropine / hyoscyamine / phenobarbital / scopolamine
Brand name: Donnatal, D-Tal, Phenohytro, Chardonna-2, Hyosophen, Donnapine, Elixiral, Bellatal, Spasmolin, Haponal, Antispas, Barbidonna, Donnatal Extentabs, Antispasmodic, Bellalphen, Donnaphen, Spasquid, Alkabel-SR, Bellatal ER, Servira, PB-Hyos, Quadrapax, Phenobarbital with Belladonna Alkaloids
Synonyms: Hyoscyamine, Atropine, Scopolamine, and Phenobarbital
Generic Name: deflazacort
Brand name: Emflaza
Synonyms: Emflaza
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Belladonna alkaloids and phenobarbital-Emicizumab
- Belladonna alkaloids and phenobarbital-Emicizumab-kxwh
- Belladonna alkaloids and phenobarbital-Emicizumab-kxwh Subcutaneous
- Belladonna alkaloids and phenobarbital-Emla
- Belladonna alkaloids and phenobarbital-Emla Topical
- Belladonna alkaloids and phenobarbital-Emo-Cort Scalp Solution Topical application
- Emflaza (Deflazacort Tablets)-Belladonna and Opium
- Emflaza (Deflazacort Tablets)-Belladonna and opium rectal
- Emflaza (Deflazacort Tablets)-Belladonna and Opium Suppository
- Emflaza (Deflazacort Tablets)-Belladonna Tincture
- Emflaza (Deflazacort Tablets)-Belladonna/Phenobarbital
- Emflaza (Deflazacort Tablets)-Belrapzo