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Belladonna alkaloids and phenobarbital and Methoxyflurane

Determining the interaction of Belladonna alkaloids and phenobarbital and Methoxyflurane and the possibility of their joint administration.

Check result:

Belladonna alkaloids and phenobarbital <> Methoxyflurane

Relevance: 02.05.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ask your doctor before using PHENobarbital together with methoxyflurane. This can cause serious side effects on your kidneys. Call your doctor if your experience fever, chills, body aches, flu symptoms, and severe pain in your upper stomach spreading to your back. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Barbiturates may increase risk of methoxyflurane-induced nephrotoxicity. Laboratory and animal studies have demonstrated that barbiturates increase the metabolism of methoxyflurane to nephrotoxic metabolities (particularly inorganic fluoride), probably by CYP450 induction.

MANAGEMENT: Methoxyflurane should generally not be administered to patients receiving barbiturates concurrently and for several weeks after barbiturates have been discontinued.

References

Cousins MJ, Mazze RI "Methoxyfluranne nephrotoxicity. A study of dose response in man." JAMA 225 (1973): 1611-6
Brodeur J, Paquin P, Authier L, Geadah D, Yamauchi M, Cote MG "Influence of phenobarbital pretreatment on methoxyflurane and sodium fluoride nephropathy in Fischer 344 Rats." Toxicol Appl Pharmacol 37 (1976): 349-61
Churchill D, Yacoub JM, Siu KP, Symes A, Gault MH "Toxic nephropathy after low-dose methoxyflurane anesthesia: drug interaction with secobarbital?" Can Med Assoc J 114 (1976): 326-329, 333

Belladonna alkaloids and phenobarbital

Generic Name: atropine / hyoscyamine / phenobarbital / scopolamine

Brand name: Donnatal, D-Tal, Phenohytro, Chardonna-2, Hyosophen, Donnapine, Elixiral, Bellatal, Spasmolin, Haponal, Antispas, Barbidonna, Donnatal Extentabs, Antispasmodic, Bellalphen, Donnaphen, Spasquid, Alkabel-SR, Bellatal ER, Servira, PB-Hyos, Quadrapax, Phenobarbital with Belladonna Alkaloids

Synonyms: Hyoscyamine, Atropine, Scopolamine, and Phenobarbital

What is Belladonna alkaloids and phenobarbital?

Methoxyflurane

Generic Name: methoxyflurane

Brand name:

Synonyms: n.a.

What is Methoxyflurane?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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