Belsomra and Seconal Sodium

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Secobarbital may reduce the blood levels of suvorexant in some patients, which may make the medication less effective in treating insomnia. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with inducers of CYP450 3A4 may decrease the plasma concentrations of suvorexant, which is primarily metabolized by the isoenzyme. According to the product labeling, suvorexant peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by approximately 70% and 90%, respectively, when coadministered with the potent CYP450 3A4 inducer rifampin (600 mg). No data are available for use with other, less potent inducers.

MANAGEMENT: The potential for diminished therapeutic effects of suvorexant should be considered when prescribed with inducers of CYP450 3A4. Pharmacologic effects of suvorexant should be monitored more closely whenever an inducer is added to or withdrawn from therapy, and the suvorexant dosage adjusted as necessary.

Belsomra

Generic Name: suvorexant

Brand name: Belsomra

Synonyms: n.a.

What is Belsomra?

Seconal Sodium

Generic Name: secobarbital

Brand name: Seconal Sodium, Seconal

Synonyms: n.a.

What is Seconal Sodium?