Bendamustine Hydrochloride and Demadex

• Generic Name: bendamustine
• Dosage Forms: n.a.
• Other Brand Names: Belrapzo, Bendeka, Treanda

Treatment of chronic lymphocytic leukemia (CLL) (designated an orphan drug by FDA for this use).

Prolonged progression-free survival and increased overall response rate observed with bendamustine compared with chlorambucil in patients with previously untreated, Binet stage B or C (Rai stages I–IV) CLL. Incidence of adverse effects generally also higher with bendamustine than with chlorambucil.

Efficacy of bendamustine relative to first-line therapies other than chlorambucil not established.

Treatment of rituximab-refractory, indolent, B-cell non-Hodgkin’s lymphoma (NHL).

Use in combination with rituximab for treatment of previously untreated advanced-stage indolent NHL or for treatment of previously untreated advanced-stage mantle cell lymphoma is a reasonable choice (accepted, with possible conditions); however, consider histologic subtype of NHL when selecting a combination chemotherapy regimen.

Use in combination with rituximab for treatment of relapsed or refractory indolent NHL or for treatment of relapsed or refractory mantle cell lymphoma is recommended (accepted).

• Generic Name: torsemide
• Dosage Forms: tablet
• Other Brand Names: Demadex, Demadex IV.

Demadex is a loop diuretic (water pill) that prevents your body from absorbing too much salt, allowing the salt to instead be passed in your urine.

Demadex treats fluid retention (edema) in people with congestive heart failure, liver disease, kidney disease, or kidney failure. This medication is also used to treat high blood pressure (hypertension).

Demadex may also be used for purposes not listed in this medication guide.