Bendamustine Hydrochloride and Diamox Sequels

• Generic Name: bendamustine
• Dosage Forms: n.a.
• Other Brand Names: Belrapzo, Bendeka, Treanda

Treatment of chronic lymphocytic leukemia (CLL) (designated an orphan drug by FDA for this use).

Prolonged progression-free survival and increased overall response rate observed with bendamustine compared with chlorambucil in patients with previously untreated, Binet stage B or C (Rai stages I–IV) CLL. Incidence of adverse effects generally also higher with bendamustine than with chlorambucil.

Efficacy of bendamustine relative to first-line therapies other than chlorambucil not established.

Treatment of rituximab-refractory, indolent, B-cell non-Hodgkin’s lymphoma (NHL).

Use in combination with rituximab for treatment of previously untreated advanced-stage indolent NHL or for treatment of previously untreated advanced-stage mantle cell lymphoma is a reasonable choice (accepted, with possible conditions); however, consider histologic subtype of NHL when selecting a combination chemotherapy regimen.

Use in combination with rituximab for treatment of relapsed or refractory indolent NHL or for treatment of relapsed or refractory mantle cell lymphoma is recommended (accepted).

• Generic Name: acetazolamide
• Dosage Forms: n.a.
• Other Brand Names: Diamox, Diamox Sequels

Diamox Sequels reduces the activity of a protein in your body called carbonic anhydrase. Blocking this protein can help reduce the build-up of certain fluids in the body.

Diamox Sequels is used in people with certain types of glaucoma to reduce the amount of fluid in the eye, which decreases pressure inside the eye.

Diamox Sequels is also used as a diuretic ("water pill") in people with congestive heart failure, to reduce the build-up of fluid in the body. This build-up is called edema.

Diamox Sequels is also used to treat certain types of seizures, and to treat or prevent altitude sickness.

Diamox Sequels may also be used for purposes not listed in this medication guide.