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Benemid and Genpril

Determining the interaction of Benemid and Genpril and the possibility of their joint administration.

Check result:

Benemid <> Genpril

Relevance: 19.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Probenecid may interfere with the plasma protein binding, metabolism, and/or renal elimination of nonsteroidal anti-inflammatory drugs (NSAIDs), resulting in increased NSAID plasma levels. The risk of NSAID toxicity may be increased. Although adverse effects from this interaction have not been reported, patients receiving this combination should be monitored for increased NSAID side effects. Patients should be advised to report possible signs of NSAID toxicity such as dizziness, drowsiness, headache, tinnitus, nausea, vomiting, dyspepsia, abdominal pain, diarrhea, or black tarry stools.

References

Upton RA, Williams RL, Buskin JN, Jones RM "Effects of probenecid in ketoprofen kinetics." Clin Pharmacol Ther 31 (1982): 705-12
Brogden RN, Heel RC, Speight TM, Avery GS "Naproxen up to date: a review of its pharmacological properties and therapeutic efficacy and use in rheumatic diseases and pain states." Drugs 18 (1979): 241-77
Diamond JS, Paolino JS "Evidence for a postsecretory reabsorptive site for uric acid in man." J Clin Invest 52 (1973): 1491-9
Macdonald JI, Wallace SM, Herman RJ, Verbeeck RK "Effect of propenecid on the formation and elimination kinetics of the sulphate and glucuronide conjugates of diflunisal." Eur J Clin Pharmacol 47 (1995): 519-23
Sinclair H, Gibson T "Interaction between probenecid and indomethacin." Br J Rheumatol 25 (1986): 316-7
Mroszczak EJ, Combs DL, Goldblum R, et al "The effect of probenecid on ketorolac pharmacokinetics after oral dosing of ketorolac tromethamine." Clin Pharmacol Ther 51 (1992): 154
Runkel R, Mroszczak E, Chaplin M, et al "Naproxen-probenecid interaction." Clin Pharmacol Ther 24 (1978): 706-13
Foster RT, Jamali F, Russell AS "Pharmacokinetics of ketoprofen anentiomers in cholecystectomy patients: influence of probenecid." Eur J Clin Pharmacol 37 (1989): 589-94

Benemid

Generic Name: probenecid

Brand name: Benemid

Synonyms: n.a.

What is Benemid?

Genpril

Generic Name: ibuprofen

Brand name: Advil, Genpril, Ibu, Midol IB, Motrin IB, Proprinal, Smart Sense Children's Ibuprofen, Advil Liqui-Gels, Midol, Motrin, Motrin Migraine Pain, PediaCare Children’s Pain Reliever/Fever Reducer, PediaCare Infant’s Pain Reliever/Fever Reducer, Caldolor, NeoProfen, Children's Motrin, Motrin Junior Strength

Synonyms: n.a.

What is Genpril?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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