Benemid and Imipenem and Cilastatin Injection

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration with probenecid may increase the plasma concentrations of carbapenem antibiotics. The mechanism involves competitive inhibition of carbapenem renal excretion via active tubular secretion. Significant pharmacokinetic alterations have been reported for some carbapenems such as doripenem and meropenem, but not for others like ertapenem and imipenem. According to the product labeling for ertapenem, coadministration with probenecid (500 mg orally every 6 hours) resulted in a 25% increase in ertapenem systemic exposure (AUC) and a 20% and 35% reduction in plasma and renal clearance, respectively. The half-life increased from 4.0 to 4.8 hours. Similar changes have been reported for imipenem. Because of the small effect on half-life, the coadministration with probenecid to extend the half-life of ertapenem or imipenem is not recommended.

Benemid

Generic Name: probenecid

Brand name: Benemid

Synonyms: n.a.

What is Benemid?

Imipenem and Cilastatin Injection

Generic Name: cilastatin / imipenem

Brand name: Primaxin IV, Primaxin IM, Primaxin IV ADD-Vantage

Synonyms: Imipenem and cilastatin, Imipenem and Cilastatin

What is Imipenem and Cilastatin Injection?