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Benemid and Lufyllin-400

Determining the interaction of Benemid and Lufyllin-400 and the possibility of their joint administration.

Check result:

Benemid <> Lufyllin-400

Relevance: 19.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Probenecid may inhibit the renal elimination of dyphylline. Dyphylline concentrations and risk of toxicity may be significantly increased. The clinical significance is unknown, as data are based on single-dose studies. Theophylline pharmacokinetics do not appear to be affected by probenecid and may be considered as an alternative.

References

May DC, Jarboe CH "Effect of probenecid on dyphylline elimination." Clin Pharmacol Ther 33 (1983): 822-5
Acara M, Carr EA Jr, Terry EN "Probenecid inhibition of the renal excretion of dyphyllin in chicken, rat and man." J Pharm Pharmacol 39 (1987): 526-30
Nadai M, Apichartpichean R, Hasegawa T, Nabeshima T "Pharmacokinetics and the effect of probenecid on the renal excretion mechanism of diprophylline." J Pharm Sci 81 (1992): 1024-7

Benemid

Generic Name: probenecid

Brand name: Benemid

Synonyms: n.a.

What is Benemid?

Lufyllin-400

Generic Name: dyphylline

Brand name:

Synonyms: n.a.

What is Lufyllin-400?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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