Benemid and Merrem IV

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using probenecid together with meropenem. Using probenecid with meropenem can increase the effects of meropenem. Let your doctor know if you have a history of seizures, kidney or liver problems. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with probenecid may increase the plasma concentrations of meropenem. The mechanism involves competitive inhibition of the renal excretion of meropenem via active tubular secretion. In pharmacokinetic studies, probenecid increased meropenem systemic exposure (AUC) by 56% and elimination half-life by 38%.

MANAGEMENT: The use of meropenem in combination with probenecid is not recommended by the manufacturer.

Benemid

Generic Name: probenecid

Brand name: Benemid

Synonyms: n.a.

What is Benemid?

Merrem IV

Generic Name: meropenem

Brand name: Merrem, Merrem Novaplus

Synonyms: Merrem

What is Merrem IV?