Benemid and Pyrazinamide

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Pyrazinamide may decrease the effects of probenecid. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Pyrazinamide may antagonize the effects of uricosuric agents such as benzbromarone, probenecid, and sulfinpyrazone. The mechanism for this interaction has not been delineated.

MANAGEMENT: Caution is advised when pyrazinamide is used concomitantly with uricosuric agents. Dosage adjustments as well as clinical and laboratory monitoring for altered uricosuric efficacy should be considered. Some authorities recommend avoiding concomitant use of pyrazinamide and probenecid (AU).

Benemid

Generic Name: probenecid

Brand name: Benemid

Synonyms: n.a.

What is Benemid?

Pyrazinamide

Generic Name: pyrazinamide

Brand name:

Synonyms: n.a.

What is Pyrazinamide?