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Benemid and Ratio-Indomethacin

Determining the interaction of Benemid and Ratio-Indomethacin and the possibility of their joint administration.

Check result:

Benemid <> Ratio-Indomethacin

Relevance: 19.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using indomethacin together with probenecid may increase the effects of indomethacin. Contact your doctor if you experience nausea, vomiting, stomach pain, drowsiness, black or bloody stools, coughing up blood, ringing in the ears, shallow breathing, or fainting. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Indomethacin clearance may be reduced during concomitant therapy with probenecid. The mechanism is unclear. Data from one study suggest that probenecid may interfere with biliary elimination of indomethacin. Other reports propose interference with the renal elimination of indomethacin. The risk of adverse effects may be increased.

MANAGEMENT: Patients receiving this combination should be monitored for increased NSAID side effects. Patients should be advised to report possible signs of NSAID toxicity such as dizziness, drowsiness, headache, tinnitus, nausea, vomiting, dyspepsia, abdominal pain, diarrhea, or black tarry stools. Dose reductions may be required.

References

Runkel R, Mroszczak E, Chaplin M, et al "Naproxen-probenecid interaction." Clin Pharmacol Ther 24 (1978): 706-13
Skeith MD, Simkin PA, Healey LA "The renal excretion of indomethacin and its inhibition by probenecid." Clin Pharmacol Ther 9 (1968): 89-93
Sinclair H, Gibson T "Interaction between probenecid and indomethacin." Br J Rheumatol 25 (1986): 316-7
Upton RA, Williams RL, Buskin JN, Jones RM "Effects of probenecid in ketoprofen kinetics." Clin Pharmacol Ther 31 (1982): 705-12
Mroszczak EJ, Combs DL, Goldblum R, et al "The effect of probenecid on ketorolac pharmacokinetics after oral dosing of ketorolac tromethamine." Clin Pharmacol Ther 51 (1992): 154
Baber N, Halliday L, Sibeon R, et al "The interaction between indomethacin and probenecid: a clinical and pharmacokinetic study." Clin Pharmacol Ther 24 (1978): 298-307

Benemid

Generic Name: probenecid

Brand name: Benemid

Synonyms: n.a.

What is Benemid?

Ratio-Indomethacin

Generic Name: indomethacin

Brand name: Indocin, Indocin SR, Tivorbex

Synonyms: Indomethacin

What is Ratio-Indomethacin?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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