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Benemid and Rifadin IV

Determining the interaction of Benemid and Rifadin IV and the possibility of their joint administration.

Check result:

Benemid <> Rifadin IV

Relevance: 19.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Probenecid may increase serum concentrations of rifampin, possibly by impairing hepatic uptake of rifampin. This effect appears to be inconsistent, occurring in some patients, but not in others.

References

Allen BW, Ellard GA, Mitchison DA, Hatfield AR, Kenwright S, Levi AJ "Probenecid and serum-rifampicin." Lancet 2 (1975): 1309
Fallon RJ, Allan GW, Lees AW, Smith J, Tyrrell WF "Probenecid and rifampicin serum levels." Lancet 2 (1975): 792-4
Venkatesan K "Pharmacokinetic drug interactions with rifampicin." Clin Pharmacokinet 22 (1992): 47-65
Kenwright S, Levi AJ "Impairment of hepatic uptake of rifamycin antibiotics by probenicid, and its therapeutic implications." Lancet 21 (1973): 1401-5

Benemid

Generic Name: probenecid

Brand name: Benemid

Synonyms: n.a.

What is Benemid?

Rifadin IV

Generic Name: rifampin

Brand name: Rifadin IV, Rifadin, Rimactane

Synonyms: n.a.

What is Rifadin IV?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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