Benemid and Sodium Phenylacetate and Sodium Benzoate

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using probenecid together with sodium phenylacetate. Probenecid may decrease the effects of sodium phenylacetate for the treatment of acute hyperammonemia in patients with urea cycle disorders. Hyperammonemia is the presence of ammonia or some of its compounds in the blood, thought to be formed from the breakdown of urea. It usually results in low temperature, weak pulse, gastroenteric symptoms, and coma. It may be appropriate to avoid using probenecid during treatment of hyperammonemia due to the urgent nature of the condition. Uncontrolled hyperammonemia can rapidly result in brain damage or death. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Probenecid is known to inhibit the renal transport of many organic compounds, including aminohippuric acid, and may affect the renal excretion of phenylacetylglutamine and hippurate, the byproducts formed when sodium phenylacetate and sodium benzoate are administered for the treatment of acute hyperammonemia in patients with urea cycle disorders. Since phenylacetylglutamine and hippurate serve as vehicles to reduce waste nitrogen levels in such patients, adequate renal excretion is necessary to treat hyperammonemia and reduce the risk of glutamine-induced neurotoxicity.

MANAGEMENT: Although the interaction is theoretical and no data are available, it may be appropriate to avoid using probenecid during treatment of acute hyperammonemia in patients with urea cycle disorders due to the urgent nature of the condition. Uncontrolled hyperammonemia can rapidly result in brain damage or death.

Benemid

Generic Name: probenecid

Brand name: Benemid

Synonyms: n.a.

What is Benemid?

Sodium Phenylacetate and Sodium Benzoate

Generic Name: sodium benzoate / sodium phenylacetate

Brand name: Ammonul

Synonyms: n.a.

What is Sodium Phenylacetate and Sodium Benzoate?