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Benemid and Trexall Oral

Determining the interaction of Benemid and Trexall Oral and the possibility of their joint administration.

Check result:

Benemid <> Trexall Oral

Relevance: 19.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using probenecid together with methotrexate can increase the methotrexate levels in your body. This can cause pale skin, easy bruising or bleeding, unusual weakness, mouth sores, nausea, vomiting, black or bloody stools, and urinating less than usual or not at all. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or special test to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR CLOSELY: Probenecid inhibits the renal elimination of methotrexate. The pharmacologic effect and toxicity of methotrexate may be increased, especially in patients receiving high-dose methotrexate.

MANAGEMENT: If this combination must be used, a reduction in methotrexate dosage may be needed and the patient should be closely monitored for signs and symptoms of bone marrow suppression, hepatotoxicity, and nephrotoxicity. Patients should be advised to promptly report symptoms including fever, chills, sore throat, bruising, bleeding, stomatitis, malaise, shortness of breath, lower extremity edema, jaundice, or change in stool or urine color to their physician.

References

Howell SB, Olshen RA, Rice JA "Effect of probenecid on cerebrospinal fluid methotrexate kinetics." Clin Pharmacol Ther 26 (1979): 641-6
Lilly MB, Omura GA "Clinical pharmacology of oral intermediate-dose methotrexate with or without probenecid." Cancer Chemother Pharmacol 15 (1985): 220-2
Aherne GW, Piall E, Marks V, et al "Prolongation and enhancement of serum methotrexate concentrations by probenecid." Br Med J 1 (1978): 1097-9
Bourke RS, Chheda G, Bremer A, Watanabe O, Tower DB "Inhibition of renal tubular transport of methotrexate by probenecid." Cancer Res 35 (1975): 110-6
Basin KS, Escalante A, Beardmore TD "Severe pancytopenia in a patient taking low dose methotrexate and probenecid." J Rheumatol 18 (1991): 609-10
Kates RE, Tozer TN, Sorby DL "Increased methotrexate toxicity due to concurrent probenecid administration." Biochem Pharmacol 25 (1976): 1485-8

Benemid

Generic Name: probenecid

Brand name: Benemid

Synonyms: n.a.

What is Benemid?

Trexall Oral

Generic Name: methotrexate

Brand name: Rheumatrex Dose Pack, Trexall, Xatmep, Otrexup, Rasuvo, Methotrexate Sodium, Preservative Free

Synonyms: Trexall

What is Trexall Oral?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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