Benztropine Mesylate and Indinavir Sulfate

• Generic Name: benztropine
• Dosage Forms: n.a.
• Other Brand Names: Cogentin

Adjunctive treatment of all forms of parkinsonian syndrome.

May be used as monotherapy or combined with other antiparkinsonian agents (e.g., carbidopa-levodopa).

Control of extrapyramidal reactions (e.g., acute dystonia) induced by antipsychotic agents (e.g., phenothiazines).

Does not alleviate symptoms of tardive dyskinesia, and in some instances may aggravate them. Use not recommended.

• Generic Name: indinavir
• Dosage Forms: n.a.
• Other Brand Names: Crixivan

Treatment of HIV infection in adults, adolescents, and pediatric patients; used in conjunction with other antiretrovirals.

Experts state indinavir not recommended for initial treatment regimens in antiretroviral-naive adults and adolescents because of inconvenient dosing regimen, fluid requirements, and toxicities (e.g., nephrolithiasis, crystalluria).

Indinavir with low-dose ritonavir (ritonavir-boosted indinavir) not recommended for initial therapy in antiretroviral-naive adults and adolescents because of fluid requirements and toxicities (e.g., nephrolithiasis, crystalluria).

Indinavir (with or without low-dose ritonavir) not recommended for initial treatment regimens in antiretroviral-naive pediatric patients because of high incidence of hematuria, sterile leukocyturia, and nephrolithiasis in children.