Betamethasone and calcipotriene topical and Telotristat Etiprate

• Generic Name: betamethasone / calcipotriene topical
• Dosage Forms: n.a.
• Other Brand Names: Enstilar, Taclonex, Taclonex Scalp, Dovobet

Betamethasone is a steroid. It prevents the release of substances in the body that cause inflammation.

Calcipotriene is a form of vitamin D. It works by decreasing the rate of skin cell reproduction.

Betamethasone and calcipotriene topical (for the skin) is a combination medicine used to treat plaque psoriasis.

Adults may use the suspension (liquid) form of betamethasone and calcipotriene on the skin or the scalp. The liquid may be used only on the scalp in children who are at least 12 years old.

Betamethasone and calcipotriene topical foam or ointment should be used only on the skin and only by adults.

Betamethasone and calcipotriene may also be used for purposes not listed in this medication guide.

• Generic Name: telotristat
• Dosage Forms: n.a.
• Other Brand Names: Xermelo

Used (in combination with somatostatin analog therapy) for treatment of carcinoid syndrome diarrhea inadequately controlled by somatostatin analog therapy alone (designated an orphan drug by FDA for the treatment of carcinoid syndrome in patients with neuroendocrine tumors).

Carcinoid syndrome, a condition associated with serotonin overproduction, is characterized by flushing, diarrhea, wheezing, occasionally congestive heart failure, and various other manifestations. Although somatostatin analogs (e.g., octreotide, lanreotide) are standard treatment for carcinoid syndrome and are effective initially in most patients, some patients may not respond adequately or may develop recurrent symptoms, including diarrhea, despite therapy.

In clinical studies, telotristat ethyl reduced the frequency of daily bowel movements in patients with carcinoid syndrome diarrhea. Reductions in other symptoms of carcinoid syndrome (e.g., abdominal pain, flushing) not observed.