Betamethasone Spray and Insulin glargine, recombinant Subcutaneous
Determining the interaction of Betamethasone Spray and Insulin glargine, recombinant Subcutaneous and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:The efficacy of insulin and other antidiabetic agents may be diminished by topical corticosteroids, particularly during prolonged or indiscriminate use. Corticosteroids can raise blood glucose level by antagonizing the action and suppressing the secretion of insulin, which results in inhibition of peripheral glucose uptake and increased gluconeogenesis. Systemic absorption of topical corticosteroids may occur depending on the vehicle and concentration of the preparation, the size of the application area, the integrity of the skin, and the duration of administration. Use of occlusive dressings over the applied areas may also increase percutaneous absorption. Given equivalent doses, small children are generally at the greatest risk because of their larger skin surface to body mass ratios. If possible, the use of highly potent agents (e.g., augmented betamethasone, clobetasol, diflorasone, and halobetasol) should be avoided in children and limited to small areas for 2 weeks in adults. Close clinical monitoring of glycemic control is recommended if topical corticosteroids are administered chronically and/or to large areas in diabetic patients.
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- Ludvik B, Clodi M, Kautzky-Willer A, Capek M, Hartter E, Pacini G, Prager R "Effect of dexamethasone on insulin sensitivity, islet amyloid polypeptide and insulin secretion in humans." Diabetologia 36 (1993): 84-7
- Seale JP, Compton MR "Side-effects of corticosteroid agents." Med J Aust 144 (1986): 139-42
- "Product Information. Psorcon (diflorasone topical)." Rhone-Poulenc Rorer, Collegeville, PA.
- Pace WE "Topical corticosteroids." Can Med Assoc J 108 (1973): 11 passim
- "Product Information. Ultravate (halobetasol)." Bristol-Myers Squibb, Princeton, NJ.
- Carruthers JA, Staughton RC, August PJ "Penetration of topical steroid preparations." Arch Dermatol 113 (1977): 522
- "Product Information. Diprolene (betamethasone topical)." Schering Laboratories, Kenilworth, NJ.
Generic Name: betamethasone topical
Brand name: Diprolene, Luxiq, Sernivo, Diprosone, Uticort, Betanate, Alphatrex, Del-Beta, Maxivate, Valisone, Beta-Val, Betatrex, Betaderm, Diprolene AF, Teladar
Synonyms: Betamethasone topical, Betamethasone (Topical)
Generic Name: insulin glargine
Brand name: Basaglar KwikPen, Lantus, Lantus Solostar Pen, Toujeo SoloStar, Lantus OptiClik Cartridge, Toujeo Max SoloStar, Lantus SoloStar
Synonyms: Insulin glargine, Insulin Glargine
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Betamethasone Spray-Insulin glulisine
- Betamethasone Spray-Insulin Glulisine (Cartridges and Pens)
- Betamethasone Spray-Insulin Glulisine (Vials)
- Betamethasone Spray-Insulin glulisine Subcutaneous
- Betamethasone Spray-Insulin human inhaled Inhalation
- Betamethasone Spray-Insulin human regular Injection
- Insulin glargine, recombinant Subcutaneous-Betamethasone topical
- Insulin glargine, recombinant Subcutaneous-Betamethasone Valerate
- Insulin glargine, recombinant Subcutaneous-Betamethasone Valerate Foam
- Insulin glargine, recombinant Subcutaneous-Betamethasone Valerate Lotion
- Insulin glargine, recombinant Subcutaneous-Betamethasone Valerate topical
- Insulin glargine, recombinant Subcutaneous-Betamethasone valerate Topical application