Betamethasone Valerate topical and Buphenyl (Sodium Phenylbutyrate Tablets)

• Generic Name: betamethasone topical
• Dosage Forms: n.a.
• Other Brand Names: Diprolene, Luxiq, Sernivo, Diprosone, Uticort, Betanate, Alphatrex, Del-Beta, Maxivate, Valisone, Beta-Val, Betatrex, Betaderm, Diprolene AF, Teladar

Relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.

Generally most effective in acute or chronic dermatoses (e.g., seborrheic or atopic dermatitis, localized neurodermatitis, anogenital pruritus, psoriasis, late phase of allergic contact dermatitis, inflammatory phase of xerosis).

Topical therapy generally preferred over systemic therapy; fewer associated adverse systemic effects.

Topical therapy generally only controls manifestations of dermatoses; eliminate cause if possible.

Topical efficacy may be increased by using a higher concentration or occlusive dressing therapy. (See Administration with Occlusive Dressing under Dosage and Administration.)

Response may vary from one topical corticosteroid preparation to another.

Anti-inflammatory activity may vary considerably depending on the vehicle, drug concentration, site of application, disease, and individual patient.

Cream and lotion (0.05% betamethasone dipropionate; 0.1% betamethasone valerate) are considered to have medium-range potency.

Foam (0.12% betamethasone valerate) is considered to have medium-range potency.

Ointment (0.05% betamethasone dipropionate) is considered to have high-range potency.

Cream, lotion, and ointment (0.05% betamethasone dipropionate) in optimized (augmented) vehicle are considered to have high-range potency.

Fixed-combination cream or lotion containing betamethasone dipropionate 0.05% and clotrimazole 1% is considered to have high-range potency.

Gel (0.05% betamethasone dipropionate) in optimized (augmented) vehicle is considered to have super-high range potency.

Used in fixed combination with clotrimazole in the treatment of symptomatic inflammatory tinea pedis, tinea cruris, and tinea corporis caused by Epidermophyton floccosum, Trichophyton rubrum, and T. mentagrophytes.

Safety and efficacy of topical betamethasone preparations in fixed combination with clotrimazole for the treatment of infections caused by zoophilic dermatophytes (e.g., Microsporum canis) have not been established.

Treatment failure of topical betamethasone preparations in fixed combination with clotrimazole in the treatment of M. canis infections has been reported.

Used in fixed combination with calcipotriene for the topical treatment of plaque psoriasis (psoriasis vulgaris) in adults.

Used in fixed combination with calcipotriene for the topical treatment of chronic, moderate to severe plaque psoriasis (psoriasis vulgaris) of the scalp in adults.

• Generic Name: sodium phenylbutyrate
• Dosage Forms: powder, tablets
• Other Brand Names: Buphenyl

• It is used to treat urea cycle problems.